Up-regulation of glutathione-related genes, enzyme activities and transport proteins in human cervical cancer cells treated with doxorubicin

Highlights • Expression of GSTA3 and GSTM1 is markedly higher in DOX-resistant KB-V1 cells. • DOX up-regulates expression of GSTA1, GSTA2, GSTA3 and GSTM1 in HeLa cells. • DOX up-regulates expression of GSTA1 and GSTA2 in KB-V1 cells. • MRP-mediated transport of DOX is not increased in HeLa or KB-V1...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2016-10, Vol.83, p.397-406
Hauptverfasser:	Drozd, Ewa, Krzysztoń-Russjan, Jolanta, Marczewska, Jadwiga, Drozd, Janina, Bubko, Irena, Bielak, Magda, Lubelska, Katarzyna, Wiktorska, Katarzyna, Chilmonczyk, Zdzisław, Anuszewska, Elżbieta, Gruber-Bzura, Beata
Format:	Artikel
Sprache:	eng
Schlagworte:	Carrier Proteins - genetics Carrier Proteins - metabolism Cell Line, Tumor Cervical cancer Doxorubicin Doxorubicin - pharmacology Female Fluorescent Antibody Technique Gene Expression Regulation, Neoplastic - drug effects Glutathione Glutathione - metabolism Glutathione Peroxidase - genetics Glutathione Peroxidase - metabolism Glutathione Reductase - genetics Glutathione Reductase - metabolism GST Humans Internal Medicine Medical Education Multidrug Resistance-Associated Proteins - genetics Multidrug Resistance-Associated Proteins - metabolism Resistance Up-Regulation - drug effects Uterine Cervical Neoplasms - enzymology Uterine Cervical Neoplasms - genetics
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Zusammenfassung:	Highlights • Expression of GSTA3 and GSTM1 is markedly higher in DOX-resistant KB-V1 cells. • DOX up-regulates expression of GSTA1, GSTA2, GSTA3 and GSTM1 in HeLa cells. • DOX up-regulates expression of GSTA1 and GSTA2 in KB-V1 cells. • MRP-mediated transport of DOX is not increased in HeLa or KB-V1 cells.
ISSN:	0753-3322 1950-6007
DOI:	10.1016/j.biopha.2016.06.051