MicroRNA-106a targets autophagy and enhances sensitivity of lung cancer cells to Src inhibitors

Highlights • Src inhibition results in autophagy activation in NSCLC cell lines. • Combining Src with autophagy inhibition results in significant cell death. • Induction of ULK1 upon Scr inhibition allows for autophagy activation. • Src inhibition causes induction of the ULK1 targeting microRNA-106a...

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Veröffentlicht in:	Lung cancer (Amsterdam, Netherlands) Netherlands), 2017-05, Vol.107, p.73-83
Hauptverfasser:	Rothschild, Sacha I, Gautschi, Oliver, Batliner, Jasmin, Gugger, Mathias, Fey, Martin F, Tschan, Mario P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - genetics Adenocarcinoma - pathology Adenocarcinoma of Lung Autophagy Autophagy - drug effects Autophagy-Related Protein-1 Homolog - genetics Benzodioxoles - pharmacology Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - pathology Cell Movement - drug effects Cell Survival - drug effects Dasatinib - pharmacology Down-Regulation - drug effects Hematology, Oncology and Palliative Medicine Humans Intracellular Signaling Peptides and Proteins - genetics Lung - pathology Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - pathology microRNA MicroRNAs - genetics Microtubule-Associated Proteins miR-106a NSCLC Protein Kinase Inhibitors - pharmacology Pulmonary/Respiratory Quinazolines - pharmacology RNA, Small Interfering Signal Transduction - drug effects Src tyrosine kinase inhibitor src-Family Kinases - antagonists & inhibitors src-Family Kinases - metabolism src-Family Kinases - pharmacology ULK1
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Beschreibung
Zusammenfassung:	Highlights • Src inhibition results in autophagy activation in NSCLC cell lines. • Combining Src with autophagy inhibition results in significant cell death. • Induction of ULK1 upon Scr inhibition allows for autophagy activation. • Src inhibition causes induction of the ULK1 targeting microRNA-106a. • Expression of the “oncogenic” miR-106a sensitizes NSCLC cells to Src inhibition.
ISSN:	0169-5002 1872-8332
DOI:	10.1016/j.lungcan.2016.06.004