Flow-cytometric analysis of reactive oxygen species in cancer cells under treatment with brassinosteroids

•Brassinosteroids induced generation of reactive oxygen species (ROS) in A549 cells.•The maximal effect was observed for (22S,23S)-28-homocastasterone.•It exhibited a 6-fold increase of ROS generation at 30μM concentration. To explore the underlying mechanism of cancer cell growth inhibition by bras...

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Veröffentlicht in:	Steroids 2017-01, Vol.117, p.11-15
Hauptverfasser:	Kisselev, Pyotr A., Panibrat, Olesya V., Sysa, Aliaksei R., Anisovich, Marina V., Zhabinskii, Vladimir N., Khripach, Vladimir A.
Format:	Artikel
Sprache:	eng
Schlagworte:	28-Homocastasterone A549 Cells Anticancer Antineoplastic Agents - pharmacology Brassinosteroids Brassinosteroids - pharmacology Cancer cell line A549 Cell Cycle - drug effects Cell Line, Tumor Cell Survival - drug effects Flow Cytometry Humans Reactive oxygen species Reactive Oxygen Species - metabolism
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