The expression pattern and functional role of REIC/Dkk-3 in the development of cutaneous squamous cell carcinoma

Highlights • REIC/Dkk-3 is involved in the early development of squamous cell carcinoma. • REIC/Dkk-3 inhibited the formation of cutaneous squamous cell carcinoma in vivo test. • The anti-cancer effect of REIC/Dkk-3 may arise from suppression of tumorigenic cancer cells and the regulation of cell cy...

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Veröffentlicht in:	Journal of dermatological science 2016-10, Vol.84 (1), p.88-96
Hauptverfasser:	Shin, Jung-Min, Choi, Dae-Kyoung, Kang, Hye-Young, Sohn, Kyung-Cheol, Lee, Young, Kim, Chang Deok, Lee, Jeung-Hoon, Park, Byung Cheol
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinogenesis Carcinoma, Squamous Cell - metabolism Cell Cycle Cell Line, Tumor Cell Movement Cell Proliferation Dermatology Expression Gene Expression Profiling Gene Expression Regulation Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Inhibition Intercellular Signaling Peptides and Proteins - metabolism Keratosis, Actinic - metabolism Mice Mice, SCID Neoplastic Stem Cells Real-Time Polymerase Chain Reaction REIC/Dkk-3 Skin - metabolism Skin Neoplasms - metabolism Squamous cell carcinoma
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Zusammenfassung:	Highlights • REIC/Dkk-3 is involved in the early development of squamous cell carcinoma. • REIC/Dkk-3 inhibited the formation of cutaneous squamous cell carcinoma in vivo test. • The anti-cancer effect of REIC/Dkk-3 may arise from suppression of tumorigenic cancer cells and the regulation of cell cycle.
ISSN:	0923-1811 1873-569X
DOI:	10.1016/j.jdermsci.2016.06.006