Ogipeptins, novel inhibitors of LPS: physicochemical properties and structural elucidation

In the course of our screening program for inhibitors of lipopolysaccharide binding to cellular receptor CD14, a potent inhibitory activity was detected in the cultured broth of Pseudoalteromonas sp. SANK 71903. Four active compounds, ogipeptins A, B, C and D, were isolated from the cultured broth....

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Veröffentlicht in:	Journal of antibiotics 2017-01, Vol.70 (1), p.84-89
Hauptverfasser:	Hirota-Takahata, Yuki, Kozuma, Shiho, Kuraya, Nahoki, Fukuda, Daisuke, Nakajima, Mutsuo, Takatsu, Toshio, Ando, Osamu
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154 692/699 Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Bacteriology Biomedical and Life Sciences Bioorganic Chemistry Life Sciences Lipopeptides - chemistry Lipopeptides - isolation & purification Lipopeptides - pharmacology Lipopolysaccharide Receptors - metabolism Lipopolysaccharides - antagonists & inhibitors Lipopolysaccharides - metabolism Medicinal Chemistry Microbiology Organic Chemistry original-article Peptides, Cyclic - chemistry Peptides, Cyclic - isolation & purification Peptides, Cyclic - pharmacology Physicochemical properties Spectrum Analysis
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Zusammenfassung:	In the course of our screening program for inhibitors of lipopolysaccharide binding to cellular receptor CD14, a potent inhibitory activity was detected in the cultured broth of Pseudoalteromonas sp. SANK 71903. Four active compounds, ogipeptins A, B, C and D, were isolated from the cultured broth. The structures of these compounds were elucidated by physicochemical data and spectral analyses, and they were determined to be new cyclic lipopeptides.
ISSN:	0021-8820 1881-1469
DOI:	10.1038/ja.2016.61