Molecular identification of miR-145 and miR-9 expression level as prognostic biomarkers for early-stage cervical cancer detection

MicroRNAs (miRNAs) may act as carcinogen or tumor suppressor genes by targeting various biological molecules. Therefore, it is important to identify significant markers for prognosis, diagnosis treatment strategies of cancers. To evaluate the clinical importance and prognostic value of miR-9 and miR-145 in cervical cancer. miRNAs expression was detected using quantitative real-time polymerase chain reaction in cervical cancer specimens and adjacent normal tissues. MiR-9 up-regulated in cervical cancer specimens than adjacent normal tissues (9.743 ± 2.172 vs. 2.131 ± 1.083; P