Dynamic single gold nanoparticle visualization by clinical intracoronary optical coherence tomography

The potential use of Gold Nanoparticles (GNPs) as contrast agents for clinical intracoronary frequency domain Optical Coherence Tomography (OCT) is here explored. The OCT contrast enhancement caused by GNPs of different sizes and morphologies has been systematically investigated and correlated with their optical properties. Among the different GNPs commercially available with plasmon resonances close to the operating wavelength of intracoronary OCT (1.3 µm), Gold Nanoshells (GNSs) have provided the best OCT contrast due to their largest scattering cross section at this wavelength. Clinical intracoronary OCT catheters are here demonstrated to be capable of three dimensional visualization and real‐time tracking of individual GNSs. Results here included open an avenue to novel application of intravascular clinical OCT in combination with GNPs, such as real time evaluation of intravascular obstructions or pressure gradients. Gold Nanoshells are efficient contrast agents for intracoronary OCT imaging due to their large scattering cross section in the 1000‐1400 infrared operating range. Clinical intracoronary OCT systems are able to detect single Gold Nanoshells in both static and dynamic conditions. The outstanding OCT contrast provided by single Gold Nanoshells opens a new avenue towards the development of new intracoronary diagnosis tools.