The Regulation of GluN2A by Endogenous and Exogenous Regulators in the Central Nervous System

The NMDA receptor is the most widely studied ionotropic glutamate receptor, and it is central to many physiological and pathophysiological processes in the central nervous system. GluN2A is one of the two main types of GluN2 NMDA receptor subunits in the forebrain. The proper activity of GluN2A is i...

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Veröffentlicht in:	Cellular and molecular neurobiology 2017-04, Vol.37 (3), p.389-403
Hauptverfasser:	Sun, Yongjun, Zhan, Liying, Cheng, Xiaokun, Zhang, Linan, Hu, Jie, Gao, Zibin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior Biomedical and Life Sciences Biomedicine Cell Biology Central nervous system Central Nervous System - metabolism Forebrain Glutamic acid Glutamic acid receptors (ionotropic) Humans Mental disorders Models, Biological N-Methyl-D-aspartic acid receptors Nervous system Neurobiology Neurosciences Receptors, N-Methyl-D-Aspartate - metabolism Regulation Review Paper Stress, Psychological - metabolism
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Beschreibung
Zusammenfassung:	The NMDA receptor is the most widely studied ionotropic glutamate receptor, and it is central to many physiological and pathophysiological processes in the central nervous system. GluN2A is one of the two main types of GluN2 NMDA receptor subunits in the forebrain. The proper activity of GluN2A is important to brain function, as the abnormal regulation of GluN2A may induce some neuropsychiatric disorders. This review will examine the regulation of GluN2A by endogenous and exogenous regulators in the central nervous system.
ISSN:	0272-4340 1573-6830 1573-6830
DOI:	10.1007/s10571-016-0388-6