The Influence of Age on the Diagnostic Performance of White Blood Cell Count and Absolute Neutrophil Count in Suspected Pediatric Appendicitis

The Influence of Age on the Diagnostic Performance of White Blood Cell Count and Absolute Neutrophil Count in Suspected Pediatric Appendicitis

Objective White blood cell (WBC) count and absolute neutrophil count (ANC) are a standard part of the evaluation of suspected appendicitis. Specific threshold values are utilized in clinical pathways, but the discriminatory value of WBC count and ANC may vary by age. The objective of this study was...

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Veröffentlicht in:Academic emergency medicine 2016-11, Vol.23 (11), p.1235-1242
Hauptverfasser: Bachur, Richard G., Dayan, Peter S., Dudley, Nanette C., Bajaj, Lalit, Stevenson, Michelle D., Macias, Charles G., Mittal, Manoj K., Bennett, Jonathan, Sinclair, Kelly, Monuteaux, Michael C., Kharbanda, Anupam B., Zonfrillo, Mark R.
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Age Factors
Appendicitis
Appendicitis - blood
Appendicitis - diagnosis
Area Under Curve
Biomarkers - blood
Child
Child, Preschool
Emergency Service, Hospital
Female
Humans
Infant
Leukocyte Count
Leukocytes
Male
Medical diagnosis
Neutrophils
Pediatrics
Performance evaluation
Prospective Studies
ROC Curve
Sensitivity and Specificity
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Zusammenfassung:Objective White blood cell (WBC) count and absolute neutrophil count (ANC) are a standard part of the evaluation of suspected appendicitis. Specific threshold values are utilized in clinical pathways, but the discriminatory value of WBC count and ANC may vary by age. The objective of this study was to investigate whether the diagnostic value of WBC count and ANC varies across age groups and whether diagnostic thresholds should be age‐adjusted. Methods This is a multicenter prospective observational study of patients aged 3–18 years who were evaluated for appendicitis. Receiver operator characteristic curves were developed to assess overall discriminative power of WBC count and ANC across three age groups:
ISSN:1069-6563
1553-2712
DOI:10.1111/acem.13018