Circulating tight junction proteins mirror blood–brain barrier integrity in leukaemia central nervous system metastasis
The aim of this study was to evaluate the clinical significance of circulating tight junction (TJ) proteins as biomarkers reflecting of leukaemia central nervous system (CNS) metastasis. TJs [claudin5 (CLDN5), occludin (OCLN) and ZO‐1] concentrations were measured in serum and cerebrospinal fluid (C...
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| Veröffentlicht in: | Hematological oncology 2017-09, Vol.35 (3), p.365-373 |
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| container_title | Hematological oncology |
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| creator | Zhu, Jing‐cheng Si, Meng‐ya Li, Ya‐zhen Chen, Huan‐zhu Fan, Zhi‐cheng Xie, Qing‐dong Jiao, Xiao‐yang |
| description | The aim of this study was to evaluate the clinical significance of circulating tight junction (TJ) proteins as biomarkers reflecting of leukaemia central nervous system (CNS) metastasis. TJs [claudin5 (CLDN5), occludin (OCLN) and ZO‐1] concentrations were measured in serum and cerebrospinal fluid (CSF) samples obtained from 45 leukaemia patients. Serum ZO‐1 was significantly higher (p |
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TJs [claudin5 (CLDN5), occludin (OCLN) and ZO‐1] concentrations were measured in serum and cerebrospinal fluid (CSF) samples obtained from 45 leukaemia patients. Serum ZO‐1 was significantly higher (p < 0.05), but CSF ZO‐1 levels were not significantly higher in the CNS leukaemia (CNSL) compared to the non‐CNSL. The CNSL patients also had a lower CLDN5/ZO1 ratio in both serum and CSF than in non‐CNSL patients (p < 0.05). The TJ index was negatively associated with WBCCSF, ALBCSF and BBB values in leukaemia patients. Among all of the parameters studied, CLDN5CSF had the highest specificity in discriminating between CNSL and non‐CNSL patients. Therefore, analysing serum and CSF levels of CLDN5, OCLN and the CLDN5/ZO1 ratio is valuable in evaluating the potential of leukaemia CNS metastasis. Copyright © 2016 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0278-0232</identifier><identifier>EISSN: 1099-1069</identifier><identifier>DOI: 10.1002/hon.2289</identifier><identifier>PMID: 26999811</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adolescent ; Adult ; Biomarkers ; Blood circulation ; Blood-brain barrier ; Blood-Brain Barrier - metabolism ; Blood-Brain Barrier - pathology ; Central nervous system ; Central Nervous System Neoplasms - diagnosis ; Central Nervous System Neoplasms - metabolism ; Central Nervous System Neoplasms - mortality ; Central Nervous System Neoplasms - secondary ; Cerebrospinal fluid ; Child ; Claudin-5 - blood ; Claudin-5 - cerebrospinal fluid ; claudin‐5 ; Female ; Humans ; leukaemia ; Leukemia ; Leukemia - pathology ; Male ; Metastases ; Metastasis ; Nervous system ; occludin ; Occludin - blood ; Occludin - cerebrospinal fluid ; Patient Outcome Assessment ; Patients ; Prognosis ; Proteins ; ROC Curve ; tight junction protein ; Tight Junction Proteins - blood ; Tight Junction Proteins - cerebrospinal fluid ; Young Adult ; Zonula occludens-1 protein ; Zonula Occludens-1 Protein - blood ; Zonula Occludens-1 Protein - cerebrospinal fluid ; ZO‐1</subject><ispartof>Hematological oncology, 2017-09, Vol.35 (3), p.365-373</ispartof><rights>Copyright © 2016 John Wiley & Sons, Ltd.</rights><rights>Copyright © 2017 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3169-8d6c204a1c3c22f1927c37371d1e283362ccc51cac21daee84ae78b3cf751afc3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhon.2289$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhon.2289$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26999811$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhu, Jing‐cheng</creatorcontrib><creatorcontrib>Si, Meng‐ya</creatorcontrib><creatorcontrib>Li, Ya‐zhen</creatorcontrib><creatorcontrib>Chen, Huan‐zhu</creatorcontrib><creatorcontrib>Fan, Zhi‐cheng</creatorcontrib><creatorcontrib>Xie, Qing‐dong</creatorcontrib><creatorcontrib>Jiao, Xiao‐yang</creatorcontrib><title>Circulating tight junction proteins mirror blood–brain barrier integrity in leukaemia central nervous system metastasis</title><title>Hematological oncology</title><addtitle>Hematol Oncol</addtitle><description>The aim of this study was to evaluate the clinical significance of circulating tight junction (TJ) proteins as biomarkers reflecting of leukaemia central nervous system (CNS) metastasis. TJs [claudin5 (CLDN5), occludin (OCLN) and ZO‐1] concentrations were measured in serum and cerebrospinal fluid (CSF) samples obtained from 45 leukaemia patients. Serum ZO‐1 was significantly higher (p < 0.05), but CSF ZO‐1 levels were not significantly higher in the CNS leukaemia (CNSL) compared to the non‐CNSL. The CNSL patients also had a lower CLDN5/ZO1 ratio in both serum and CSF than in non‐CNSL patients (p < 0.05). The TJ index was negatively associated with WBCCSF, ALBCSF and BBB values in leukaemia patients. Among all of the parameters studied, CLDN5CSF had the highest specificity in discriminating between CNSL and non‐CNSL patients. Therefore, analysing serum and CSF levels of CLDN5, OCLN and the CLDN5/ZO1 ratio is valuable in evaluating the potential of leukaemia CNS metastasis. Copyright © 2016 John Wiley & Sons, Ltd.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biomarkers</subject><subject>Blood circulation</subject><subject>Blood-brain barrier</subject><subject>Blood-Brain Barrier - metabolism</subject><subject>Blood-Brain Barrier - pathology</subject><subject>Central nervous system</subject><subject>Central Nervous System Neoplasms - diagnosis</subject><subject>Central Nervous System Neoplasms - metabolism</subject><subject>Central Nervous System Neoplasms - mortality</subject><subject>Central Nervous System Neoplasms - secondary</subject><subject>Cerebrospinal fluid</subject><subject>Child</subject><subject>Claudin-5 - blood</subject><subject>Claudin-5 - cerebrospinal fluid</subject><subject>claudin‐5</subject><subject>Female</subject><subject>Humans</subject><subject>leukaemia</subject><subject>Leukemia</subject><subject>Leukemia - pathology</subject><subject>Male</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Nervous system</subject><subject>occludin</subject><subject>Occludin - blood</subject><subject>Occludin - cerebrospinal fluid</subject><subject>Patient Outcome Assessment</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Proteins</subject><subject>ROC Curve</subject><subject>tight junction protein</subject><subject>Tight Junction Proteins - blood</subject><subject>Tight Junction Proteins - cerebrospinal fluid</subject><subject>Young Adult</subject><subject>Zonula occludens-1 protein</subject><subject>Zonula Occludens-1 Protein - blood</subject><subject>Zonula Occludens-1 Protein - cerebrospinal fluid</subject><subject>ZO‐1</subject><issn>0278-0232</issn><issn>1099-1069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkcFqGzEQhkVoiN200Ccogl5yWUcjxVrpWEwTF0xySc5Cqx07cne1qaRN2VveoW-YJ4lMkh4KA__A_zHMzE_IF2ALYIyf3w9hwbnSR2QOTOsKmNQfyJzxWlWMCz4jH1PaM1Y8pk7IjEuttQKYk2nloxs7m33Y0ex395nux-CyHwJ9iENGHxLtfYxDpE03DO3z098mWh9oY2P0GKkPGXfR56l0tMPxl8XeW-ow5Gg7GjA-DmOiaUoZe9pjtqmUT5_I8dZ2CT-_6Sm5u_xxu1pXm5urn6vvm8oJkLpSrXScXVhwwnG-Bc1rJ2pRQwvIlRCSO-eW4Kzj0FpEdWGxVo1w23oJduvEKTl7nVvO-T1iyqb3yWHX2YBlMQOKSym1ZFDQb_-h-2GMoWxnQAu15KqGZaG-vlFj02NrHqLvbZzM-1MLUL0Cf3yH0z8fmDmEZUpY5hCWWd9cH1S8ACiBiho</recordid><startdate>201709</startdate><enddate>201709</enddate><creator>Zhu, Jing‐cheng</creator><creator>Si, Meng‐ya</creator><creator>Li, Ya‐zhen</creator><creator>Chen, Huan‐zhu</creator><creator>Fan, Zhi‐cheng</creator><creator>Xie, Qing‐dong</creator><creator>Jiao, Xiao‐yang</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QL</scope><scope>7QO</scope><scope>7QP</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201709</creationdate><title>Circulating tight junction proteins mirror blood–brain barrier integrity in leukaemia central nervous system metastasis</title><author>Zhu, Jing‐cheng ; 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TJs [claudin5 (CLDN5), occludin (OCLN) and ZO‐1] concentrations were measured in serum and cerebrospinal fluid (CSF) samples obtained from 45 leukaemia patients. Serum ZO‐1 was significantly higher (p < 0.05), but CSF ZO‐1 levels were not significantly higher in the CNS leukaemia (CNSL) compared to the non‐CNSL. The CNSL patients also had a lower CLDN5/ZO1 ratio in both serum and CSF than in non‐CNSL patients (p < 0.05). The TJ index was negatively associated with WBCCSF, ALBCSF and BBB values in leukaemia patients. Among all of the parameters studied, CLDN5CSF had the highest specificity in discriminating between CNSL and non‐CNSL patients. Therefore, analysing serum and CSF levels of CLDN5, OCLN and the CLDN5/ZO1 ratio is valuable in evaluating the potential of leukaemia CNS metastasis. Copyright © 2016 John Wiley & Sons, Ltd.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>26999811</pmid><doi>10.1002/hon.2289</doi><tpages>9</tpages></addata></record> |
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| subjects | Adolescent Adult Biomarkers Blood circulation Blood-brain barrier Blood-Brain Barrier - metabolism Blood-Brain Barrier - pathology Central nervous system Central Nervous System Neoplasms - diagnosis Central Nervous System Neoplasms - metabolism Central Nervous System Neoplasms - mortality Central Nervous System Neoplasms - secondary Cerebrospinal fluid Child Claudin-5 - blood Claudin-5 - cerebrospinal fluid claudin‐5 Female Humans leukaemia Leukemia Leukemia - pathology Male Metastases Metastasis Nervous system occludin Occludin - blood Occludin - cerebrospinal fluid Patient Outcome Assessment Patients Prognosis Proteins ROC Curve tight junction protein Tight Junction Proteins - blood Tight Junction Proteins - cerebrospinal fluid Young Adult Zonula occludens-1 protein Zonula Occludens-1 Protein - blood Zonula Occludens-1 Protein - cerebrospinal fluid ZO‐1 |
| title | Circulating tight junction proteins mirror blood–brain barrier integrity in leukaemia central nervous system metastasis |
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