Circulating tight junction proteins mirror blood–brain barrier integrity in leukaemia central nervous system metastasis

The aim of this study was to evaluate the clinical significance of circulating tight junction (TJ) proteins as biomarkers reflecting of leukaemia central nervous system (CNS) metastasis. TJs [claudin5 (CLDN5), occludin (OCLN) and ZO‐1] concentrations were measured in serum and cerebrospinal fluid (C...

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Veröffentlicht in:	Hematological oncology 2017-09, Vol.35 (3), p.365-373
Hauptverfasser:	Zhu, Jing‐cheng, Si, Meng‐ya, Li, Ya‐zhen, Chen, Huan‐zhu, Fan, Zhi‐cheng, Xie, Qing‐dong, Jiao, Xiao‐yang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Biomarkers Blood circulation Blood-brain barrier Blood-Brain Barrier - metabolism Blood-Brain Barrier - pathology Central nervous system Central Nervous System Neoplasms - diagnosis Central Nervous System Neoplasms - metabolism Central Nervous System Neoplasms - mortality Central Nervous System Neoplasms - secondary Cerebrospinal fluid Child Claudin-5 - blood Claudin-5 - cerebrospinal fluid claudin‐5 Female Humans leukaemia Leukemia Leukemia - pathology Male Metastases Metastasis Nervous system occludin Occludin - blood Occludin - cerebrospinal fluid Patient Outcome Assessment Patients Prognosis Proteins ROC Curve tight junction protein Tight Junction Proteins - blood Tight Junction Proteins - cerebrospinal fluid Young Adult Zonula occludens-1 protein Zonula Occludens-1 Protein - blood Zonula Occludens-1 Protein - cerebrospinal fluid ZO‐1
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Zusammenfassung:	The aim of this study was to evaluate the clinical significance of circulating tight junction (TJ) proteins as biomarkers reflecting of leukaemia central nervous system (CNS) metastasis. TJs [claudin5 (CLDN5), occludin (OCLN) and ZO‐1] concentrations were measured in serum and cerebrospinal fluid (CSF) samples obtained from 45 leukaemia patients. Serum ZO‐1 was significantly higher (p
ISSN:	0278-0232 1099-1069
DOI:	10.1002/hon.2289