Changes in hunger and fullness in relation to gut peptides before and after 8 weeks of alternate day fasting
Summary Background & aims Alternate day fasting (ADF; 25% energy intake “fast day”, alternated with an ad libitum intake “feed day”) is effective for weight loss. Whether or not ADF modulates hunger, fullness and gut peptides in a way that enhances dietary compliance and weight loss, remains unk...
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| Veröffentlicht in: | Clinical nutrition (Edinburgh, Scotland) Scotland), 2016-12, Vol.35 (6), p.1380-1385 |
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| container_title | Clinical nutrition (Edinburgh, Scotland) |
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| creator | Hoddy, Kristin K Gibbons, Catherine Kroeger, Cynthia M Trepanowski, John F Barnosky, Adrienne Bhutani, Surabhi Gabel, Kelsey Finlayson, Graham Varady, Krista A |
| description | Summary Background & aims Alternate day fasting (ADF; 25% energy intake “fast day”, alternated with an ad libitum intake “feed day”) is effective for weight loss. Whether or not ADF modulates hunger, fullness and gut peptides in a way that enhances dietary compliance and weight loss, remains unknown. Accordingly, this study examined the effect of ADF on postprandial appetite ratings and gut peptides. Methods Obese subjects (n = 59) participated in an 8-week ADF protocol where food was provided on the fast day. Results Body weight decreased (P |
| doi_str_mv | 10.1016/j.clnu.2016.03.011 |
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Whether or not ADF modulates hunger, fullness and gut peptides in a way that enhances dietary compliance and weight loss, remains unknown. Accordingly, this study examined the effect of ADF on postprandial appetite ratings and gut peptides. Methods Obese subjects (n = 59) participated in an 8-week ADF protocol where food was provided on the fast day. Results Body weight decreased (P < 0.0001) by 3.9 ± 0.6 kg after 8 weeks of diet. Reductions (P < 0.05) in fat mass (−2.2 ± 0.2 kg), fat free mass (−1.4 ± 0.2 kg), visceral fat mass (−0.1 ± 0.1 kg), and resting metabolic rate (RMR; −104 ± 28 kcal/day) were also observed. Fasting leptin and insulin decreased (P < 0.05), while AUC ghrelin levels increased (P < 0.05). Despite these metabolic changes, there was no increase in subjective hunger by the end of the study. Furthermore, fullness and PYY increased (P < 0.05). Fat free mass and RMR were not related to hunger or ghrelin at any time point. Conclusion These findings suggest that the absence of a compensatory increase in hunger in conjunction with an increase in sensations of fullness may contribute to the weight loss efficacy of an 8-week ADF regimen.]]></description><identifier>ISSN: 0261-5614</identifier><identifier>EISSN: 1532-1983</identifier><identifier>DOI: 10.1016/j.clnu.2016.03.011</identifier><identifier>PMID: 27062219</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Alternate day fasting ; Basal Metabolism ; Blood Glucose - metabolism ; Body Composition ; Body Mass Index ; Body Weight ; Calorie restriction ; Diet ; Diet Records ; Exercise ; Fasting ; Female ; Fullness ; Gastroenterology and Hepatology ; Ghrelin - blood ; Gut peptides ; Humans ; Hunger ; Insulin - blood ; Leptin - blood ; Male ; Middle Aged ; Obese adults ; Patient Compliance ; Peptide YY - blood ; Satiation</subject><ispartof>Clinical nutrition (Edinburgh, Scotland), 2016-12, Vol.35 (6), p.1380-1385</ispartof><rights>Elsevier Ltd and European Society for Clinical Nutrition and Metabolism</rights><rights>2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism</rights><rights>Copyright © 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-dd4b57f3a05421020a97d4b95070c378a1ab4eed1c9db34b95a0e48835b9c9c03</citedby><cites>FETCH-LOGICAL-c411t-dd4b57f3a05421020a97d4b95070c378a1ab4eed1c9db34b95a0e48835b9c9c03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0261561416001023$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27062219$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hoddy, Kristin K</creatorcontrib><creatorcontrib>Gibbons, Catherine</creatorcontrib><creatorcontrib>Kroeger, Cynthia M</creatorcontrib><creatorcontrib>Trepanowski, John F</creatorcontrib><creatorcontrib>Barnosky, Adrienne</creatorcontrib><creatorcontrib>Bhutani, Surabhi</creatorcontrib><creatorcontrib>Gabel, Kelsey</creatorcontrib><creatorcontrib>Finlayson, Graham</creatorcontrib><creatorcontrib>Varady, Krista A</creatorcontrib><title>Changes in hunger and fullness in relation to gut peptides before and after 8 weeks of alternate day fasting</title><title>Clinical nutrition (Edinburgh, Scotland)</title><addtitle>Clin Nutr</addtitle><description><![CDATA[Summary Background & aims Alternate day fasting (ADF; 25% energy intake “fast day”, alternated with an ad libitum intake “feed day”) is effective for weight loss. Whether or not ADF modulates hunger, fullness and gut peptides in a way that enhances dietary compliance and weight loss, remains unknown. Accordingly, this study examined the effect of ADF on postprandial appetite ratings and gut peptides. Methods Obese subjects (n = 59) participated in an 8-week ADF protocol where food was provided on the fast day. Results Body weight decreased (P < 0.0001) by 3.9 ± 0.6 kg after 8 weeks of diet. Reductions (P < 0.05) in fat mass (−2.2 ± 0.2 kg), fat free mass (−1.4 ± 0.2 kg), visceral fat mass (−0.1 ± 0.1 kg), and resting metabolic rate (RMR; −104 ± 28 kcal/day) were also observed. Fasting leptin and insulin decreased (P < 0.05), while AUC ghrelin levels increased (P < 0.05). Despite these metabolic changes, there was no increase in subjective hunger by the end of the study. Furthermore, fullness and PYY increased (P < 0.05). Fat free mass and RMR were not related to hunger or ghrelin at any time point. Conclusion These findings suggest that the absence of a compensatory increase in hunger in conjunction with an increase in sensations of fullness may contribute to the weight loss efficacy of an 8-week ADF regimen.]]></description><subject>Alternate day fasting</subject><subject>Basal Metabolism</subject><subject>Blood Glucose - metabolism</subject><subject>Body Composition</subject><subject>Body Mass Index</subject><subject>Body Weight</subject><subject>Calorie restriction</subject><subject>Diet</subject><subject>Diet Records</subject><subject>Exercise</subject><subject>Fasting</subject><subject>Female</subject><subject>Fullness</subject><subject>Gastroenterology and Hepatology</subject><subject>Ghrelin - blood</subject><subject>Gut peptides</subject><subject>Humans</subject><subject>Hunger</subject><subject>Insulin - blood</subject><subject>Leptin - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Obese adults</subject><subject>Patient Compliance</subject><subject>Peptide YY - blood</subject><subject>Satiation</subject><issn>0261-5614</issn><issn>1532-1983</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU-LFDEQxYMo7uzqF_AgOXrptpJ0-g-IIIO6woIH9RzSSfVsZjPpMUmvzLc3vbN68OApReW9B-9XhLxiUDNg7dt9bXxYal7mGkQNjD0hGyYFr9jQi6dkA7xllWxZc0EuU9oDgBRd_5xc8A5aztmwIX57q8MOE3WB3i5lilQHS6fF-4DpYR3R6-zmQPNMd0umRzxmZ4tlxGmO-KDXUy7Onv5CvEt0nqj2ZRF0Rmr1iU46ZRd2L8izSfuELx_fK_Lj08fv2-vq5uvnL9sPN5VpGMuVtc0ou0lokA1nwEEPXVkNEjowpYBmemwQLTODHcX6oQGbvhdyHMxgQFyRN-fcY5x_LpiyOrhk0HsdcF6SYj1v21bKQRYpP0tNnFOKOKljdAcdT4qBWimrvVopq5WyAqEK5WJ6_Zi_jAe0fy1_sBbBu7MAS8t7h1El4zAYtC6iycrO7v_57_-xG--CM9rf4QnTfl4KWl96qMQVqG_rndczsxag8BLiN-o3ouU</recordid><startdate>20161201</startdate><enddate>20161201</enddate><creator>Hoddy, Kristin K</creator><creator>Gibbons, Catherine</creator><creator>Kroeger, Cynthia M</creator><creator>Trepanowski, John F</creator><creator>Barnosky, Adrienne</creator><creator>Bhutani, Surabhi</creator><creator>Gabel, Kelsey</creator><creator>Finlayson, Graham</creator><creator>Varady, Krista A</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20161201</creationdate><title>Changes in hunger and fullness in relation to gut peptides before and after 8 weeks of alternate day fasting</title><author>Hoddy, Kristin K ; Gibbons, Catherine ; Kroeger, Cynthia M ; Trepanowski, John F ; Barnosky, Adrienne ; Bhutani, Surabhi ; Gabel, Kelsey ; Finlayson, Graham ; Varady, Krista A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-dd4b57f3a05421020a97d4b95070c378a1ab4eed1c9db34b95a0e48835b9c9c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Alternate day fasting</topic><topic>Basal Metabolism</topic><topic>Blood Glucose - metabolism</topic><topic>Body Composition</topic><topic>Body Mass Index</topic><topic>Body Weight</topic><topic>Calorie restriction</topic><topic>Diet</topic><topic>Diet Records</topic><topic>Exercise</topic><topic>Fasting</topic><topic>Female</topic><topic>Fullness</topic><topic>Gastroenterology and Hepatology</topic><topic>Ghrelin - blood</topic><topic>Gut peptides</topic><topic>Humans</topic><topic>Hunger</topic><topic>Insulin - blood</topic><topic>Leptin - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Obese adults</topic><topic>Patient Compliance</topic><topic>Peptide YY - blood</topic><topic>Satiation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hoddy, Kristin K</creatorcontrib><creatorcontrib>Gibbons, Catherine</creatorcontrib><creatorcontrib>Kroeger, Cynthia M</creatorcontrib><creatorcontrib>Trepanowski, John F</creatorcontrib><creatorcontrib>Barnosky, Adrienne</creatorcontrib><creatorcontrib>Bhutani, Surabhi</creatorcontrib><creatorcontrib>Gabel, Kelsey</creatorcontrib><creatorcontrib>Finlayson, Graham</creatorcontrib><creatorcontrib>Varady, Krista A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical nutrition (Edinburgh, Scotland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hoddy, Kristin K</au><au>Gibbons, Catherine</au><au>Kroeger, Cynthia M</au><au>Trepanowski, John F</au><au>Barnosky, Adrienne</au><au>Bhutani, Surabhi</au><au>Gabel, Kelsey</au><au>Finlayson, Graham</au><au>Varady, Krista A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in hunger and fullness in relation to gut peptides before and after 8 weeks of alternate day fasting</atitle><jtitle>Clinical nutrition (Edinburgh, Scotland)</jtitle><addtitle>Clin Nutr</addtitle><date>2016-12-01</date><risdate>2016</risdate><volume>35</volume><issue>6</issue><spage>1380</spage><epage>1385</epage><pages>1380-1385</pages><issn>0261-5614</issn><eissn>1532-1983</eissn><abstract><![CDATA[Summary Background & aims Alternate day fasting (ADF; 25% energy intake “fast day”, alternated with an ad libitum intake “feed day”) is effective for weight loss. Whether or not ADF modulates hunger, fullness and gut peptides in a way that enhances dietary compliance and weight loss, remains unknown. Accordingly, this study examined the effect of ADF on postprandial appetite ratings and gut peptides. Methods Obese subjects (n = 59) participated in an 8-week ADF protocol where food was provided on the fast day. Results Body weight decreased (P < 0.0001) by 3.9 ± 0.6 kg after 8 weeks of diet. Reductions (P < 0.05) in fat mass (−2.2 ± 0.2 kg), fat free mass (−1.4 ± 0.2 kg), visceral fat mass (−0.1 ± 0.1 kg), and resting metabolic rate (RMR; −104 ± 28 kcal/day) were also observed. Fasting leptin and insulin decreased (P < 0.05), while AUC ghrelin levels increased (P < 0.05). Despite these metabolic changes, there was no increase in subjective hunger by the end of the study. Furthermore, fullness and PYY increased (P < 0.05). Fat free mass and RMR were not related to hunger or ghrelin at any time point. Conclusion These findings suggest that the absence of a compensatory increase in hunger in conjunction with an increase in sensations of fullness may contribute to the weight loss efficacy of an 8-week ADF regimen.]]></abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>27062219</pmid><doi>10.1016/j.clnu.2016.03.011</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Alternate day fasting Basal Metabolism Blood Glucose - metabolism Body Composition Body Mass Index Body Weight Calorie restriction Diet Diet Records Exercise Fasting Female Fullness Gastroenterology and Hepatology Ghrelin - blood Gut peptides Humans Hunger Insulin - blood Leptin - blood Male Middle Aged Obese adults Patient Compliance Peptide YY - blood Satiation |
| title | Changes in hunger and fullness in relation to gut peptides before and after 8 weeks of alternate day fasting |
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