Recovery from ketamine-induced amnesia by blockade of GABA-A receptor in the medial prefrontal cortex of mice

Highlights • Pre-training systemic administration of ketamine decreased memory acquisition. • Pre-training intra-mPFC injection of muscimol, and baclofen, impaired memory acquisition. • Co-pretreatment of muscimol and baclofen with ketamine, caused inhibition of memory formation. • Intra-mPFC administration of bicuculline and phaclofen did not affect memory acquisition. • Amnesia induced by pre-training ketamine, decreased by pretreatment of bicuculline.