Management of Loeffler's Endocarditis With Bivalvular Involvement and a FIP1L1/PDGFRA -Negative Mutation

Abstract Hypereosinophilic syndromes (HESs) are a group of disorders characterized by end-organ damage caused by eosinophilic infiltration. We present a patient with idiopathic HES with severe tricuspid and mitral regurgitation secondary to Loeffler's endocarditis. In addition to prednisone, im...

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Veröffentlicht in:	Canadian journal of cardiology 2016-12, Vol.32 (12), p.1577.e9-1577.e11
Hauptverfasser:	Sénéchal, Mario, MD, Bernard, Pierre-Louis, MD, Cloutier, Stéphanie, MD, Leblanc, Marie-Hélène, MD, Larose, Éric, MD, Cinq-Mars, Alexandre, BSc, Dubois, Michelle, RN, BSc
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Bioprosthesis Cardiovascular Echocardiography - methods Fibrosis Genetic Testing - methods Heart Valve Prosthesis Implantation - instrumentation Heart Valve Prosthesis Implantation - methods Heart Ventricles - diagnostic imaging Heart Ventricles - pathology Humans Hypereosinophilic Syndrome - diagnosis Hypereosinophilic Syndrome - pathology Hypereosinophilic Syndrome - physiopathology Hypereosinophilic Syndrome - therapy Imatinib Mesylate - administration & dosage Magnetic Resonance Imaging, Cine - methods Male Mitral Valve - diagnostic imaging Mitral Valve - surgery Mitral Valve Insufficiency - diagnosis Mitral Valve Insufficiency - etiology Mitral Valve Insufficiency - physiopathology Mitral Valve Insufficiency - therapy Papillary Muscles - pathology Protein Kinase Inhibitors - administration & dosage Thrombosis - diagnosis Thrombosis - etiology Thrombosis - therapy Treatment Outcome Tricuspid Valve - diagnostic imaging Tricuspid Valve - surgery
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Zusammenfassung:	Abstract Hypereosinophilic syndromes (HESs) are a group of disorders characterized by end-organ damage caused by eosinophilic infiltration. We present a patient with idiopathic HES with severe tricuspid and mitral regurgitation secondary to Loeffler's endocarditis. In addition to prednisone, imatinib therapy initially helped control the eosinophil count. However, successful long-term remission was achieved with hydroxyurea therapy.
ISSN:	0828-282X 1916-7075
DOI:	10.1016/j.cjca.2015.12.034