Lateral habenula integration of proactive and retroactive information mediates behavioral flexibility

Lateral habenula integration of proactive and retroactive information mediates behavioral flexibility

Highlights • The lateral habenula is required for cued task switching. • Lateral habenula inactivation increases switch and perseverative errors. • Errors following lateral habenula inactivation occur preferentially to one cue association. • Lateral habenula inactivation does not affect non-switch c...

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Veröffentlicht in:Neuroscience 2017-03, Vol.345, p.89-98
Hauptverfasser: Baker, P.M, Raynor, S.A, Francis, N.T, Mizumori, S.J.Y
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Association
Baclofen - pharmacology
behavioral flexibility
Catheters, Indwelling
cognitive flexibility
Cues
Discrimination (Psychology) - physiology
Executive Function - physiology
Feedback, Psychological - physiology
GABA Agonists - pharmacology
habenula
Habenula - drug effects
Habenula - physiology
Male
Muscimol - pharmacology
Neurology
Neuropsychological Tests
Rats, Long-Evans
reversal learning
Reward
reward prediction error
set-shifting
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Beschreibung
Zusammenfassung:Highlights • The lateral habenula is required for cued task switching. • Lateral habenula inactivation increases switch and perseverative errors. • Errors following lateral habenula inactivation occur preferentially to one cue association. • Lateral habenula inactivation does not affect non-switch cue association performance.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2016.02.010