Implementation of Hadamard encoding for rapid multisample analysis in liquid chromatography
Multiplexing based on pseudo‐binary modulation sequences is known to increase the signal‐to‐noise ratio. In this work, Hadamard transform multiplexing is used in high‐performance liquid chromatography to increase the sample throughput. Using structured modulation sequences to encode and control samp...
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| Veröffentlicht in: | Journal of separation science 2015-11, Vol.38 (22), p.3839-3844 |
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| container_title | Journal of separation science |
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| creator | Siegle, Alexander F Trapp, Oliver |
| description | Multiplexing based on pseudo‐binary modulation sequences is known to increase the signal‐to‐noise ratio. In this work, Hadamard transform multiplexing is used in high‐performance liquid chromatography to increase the sample throughput. Using structured modulation sequences to encode and control sample injections in combination with a fitting algorithm to deconvolute the complex data allowed us to evaluate convoluted chromatograms of up to 128 samples containing three and five analytes, respectively, with good accuracy ( |
| doi_str_mv | 10.1002/jssc.201500849 |
| format | Article |
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In this work, Hadamard transform multiplexing is used in high‐performance liquid chromatography to increase the sample throughput. Using structured modulation sequences to encode and control sample injections in combination with a fitting algorithm to deconvolute the complex data allowed us to evaluate convoluted chromatograms of up to 128 samples containing three and five analytes, respectively, with good accuracy (<2% deviation). 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In comparison to conventional high‐performance liquid chromatography the analysis time could be reduced by 30 and 55%, respectively.</description><subject>accuracy</subject><subject>Algorithms</subject><subject>Chromatography</subject><subject>Deviation</subject><subject>Fittings</subject><subject>Hadamard transformation</subject><subject>high performance liquid chromatography</subject><subject>High-throughput screening</subject><subject>Liquid chromatography</subject><subject>Mass spectrometry</subject><subject>Modulation</subject><subject>Multiplexing</subject><subject>rapid methods</subject><subject>Signal to noise ratio</subject><subject>Transforms</subject><issn>1615-9306</issn><issn>1615-9314</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqF0b1v1DAYBvAIUdFSWBkhEgtLrq8_YscjOsFd6akMR8XAYDm2c_WRxFc7Edx_j6OUG7p0siX_nle2nyx7h2CBAPDVPka9wIBKgIqKF9kFYqgsBEH05WkP7Dx7HeMeAPFKwKvsHDNaspS4yH5dd4fWdrYf1OB8n_smXyujOhVMbnvtjet3eeNDHtTBmbwb28FFNWVy1av2GF3MXZ-37mFMx_o--E4Nfpf0_fFNdtaoNtq3j-tldvf1y4_luth8X10vP28KTRlhBappTQwRwAXHBHhpEFOUcNBVzVmFjQEsKFeqRiIpC1xp0FZQgxm3SpPL7NM89xD8w2jjIDsXtW1b1Vs_RokqzBghArPnKecV4LIqRaIfn9C9H0N686QIRVSUFU1qMSsdfIzBNvIQXPq9o0Qgp4bk1JA8NZQC7x_HjnVnzYn_ryQBOoM_rrXHZ8bJb9vtkpZ0elkxx1wc7N9TTIXfknHCS_nzdiVX65VYb26EvE3-w-wb5aXaBRfl3TbNTXcADKQi5B9CF7O5</recordid><startdate>201511</startdate><enddate>201511</enddate><creator>Siegle, Alexander F</creator><creator>Trapp, Oliver</creator><general>Wiley-VCH</general><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>FBQ</scope><scope>BSCLL</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>201511</creationdate><title>Implementation of Hadamard encoding for rapid multisample analysis in liquid chromatography</title><author>Siegle, Alexander F ; Trapp, Oliver</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4636-1b4b3d39079723075d16a4370c8b7682dd02947aab19390e07ac0ce94d267eac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>accuracy</topic><topic>Algorithms</topic><topic>Chromatography</topic><topic>Deviation</topic><topic>Fittings</topic><topic>Hadamard transformation</topic><topic>high performance liquid chromatography</topic><topic>High-throughput screening</topic><topic>Liquid chromatography</topic><topic>Mass spectrometry</topic><topic>Modulation</topic><topic>Multiplexing</topic><topic>rapid methods</topic><topic>Signal to noise ratio</topic><topic>Transforms</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Siegle, Alexander F</creatorcontrib><creatorcontrib>Trapp, Oliver</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of separation science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Siegle, Alexander F</au><au>Trapp, Oliver</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Implementation of Hadamard encoding for rapid multisample analysis in liquid chromatography</atitle><jtitle>Journal of separation science</jtitle><addtitle>J. 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| ispartof | Journal of separation science, 2015-11, Vol.38 (22), p.3839-3844 |
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| language | eng |
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| source | Wiley Online Library - AutoHoldings Journals |
| subjects | accuracy Algorithms Chromatography Deviation Fittings Hadamard transformation high performance liquid chromatography High-throughput screening Liquid chromatography Mass spectrometry Modulation Multiplexing rapid methods Signal to noise ratio Transforms |
| title | Implementation of Hadamard encoding for rapid multisample analysis in liquid chromatography |
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