Remodeling of ECM patch into functional myocardium in an ovine model: A pilot study

Remodeling of ECM patch into functional myocardium in an ovine model: A pilot study

Previous studies have demonstrated that surgical patches comprised of small intestinal submucosa-derived extracellular matrix (ECM) have biological remodeling potential. This pilot study investigated histological, mechanical, and bioelectrical properties of an ECM patch implanted in the ovine right-...

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Veröffentlicht in:Journal of biomedical materials research. Part B, Applied biomaterials Applied biomaterials, 2016-11, Vol.104 (8), p.1713-1720
Hauptverfasser: Scully, Brandi B., Fan, Christopher, Grigoryan, Bagrat, Jacot, Jeffrey G., Vick III, G. W., Kim, Jeffrey J., Fraser Jr, Charles D., Grande-Allen, K. J., Morales, David L. S.
Format: Artikel
Sprache:eng
Schlagworte:
angiogenesis/neovascularization
animal model
Animals
Biomedical materials
cardiovascular
Electrocardiography
Extracellular Matrix - chemistry
Female
Intestinal Mucosa - chemistry
Intestine, Small - chemistry
Materials research
Materials science
Myocardial Contraction
Myocardium
Pilot Projects
remodeling
Sheep
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Beschreibung
Zusammenfassung:Previous studies have demonstrated that surgical patches comprised of small intestinal submucosa-derived extracellular matrix (ECM) have biological remodeling potential. This pilot study investigated histological, mechanical, and bioelectrical properties of an ECM patch implanted in the ovine right-ventricular outflow tract (RVOT). ECM patches (2 × 2 cm ) were implanted in four Western Range sheep (wether males, 37-49 kg, age
ISSN:1552-4973
1552-4981
DOI:10.1002/jbm.b.33484