The delicate balance of macrophages in colorectal cancer; their role in tumour development and therapeutic potential

Highlights • Macrophages are present in high amounts in various types of cancer. • Macrophages are potent modulators of the tumour micro-environment. • Monoclonal antibody therapy in combination with macrophage activation is a promising therapy.

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Bibliographische Detailangaben
Veröffentlicht in:	Immunobiology (1979) 2017-01, Vol.222 (1), p.21-30
Hauptverfasser:	Braster, R, Bögels, M, Beelen, R.H.J, van Egmond, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Allergy and Immunology Animals Antineoplastic Agents, Immunological - pharmacology Antineoplastic Agents, Immunological - therapeutic use Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - immunology Cell Transformation, Neoplastic - metabolism Colorectal cancer Colorectal Neoplasms - etiology Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Colorectal Neoplasms - therapy Cytotoxicity, Immunologic Humans Immune therapy Immunotherapy - methods Inflammation - complications Inflammation - immunology Inflammation - metabolism Macrophage activation Macrophage Activation - genetics Macrophage Activation - immunology Macrophages Macrophages - drug effects Macrophages - immunology Macrophages - metabolism Macrophages - pathology Molecular Targeted Therapy Monoclonal antibodies
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Beschreibung
Zusammenfassung:	Highlights • Macrophages are present in high amounts in various types of cancer. • Macrophages are potent modulators of the tumour micro-environment. • Monoclonal antibody therapy in combination with macrophage activation is a promising therapy.
ISSN:	0171-2985 1878-3279
DOI:	10.1016/j.imbio.2015.08.011