Investigating the effect of TiO2 on the structure and biocompatibility of bioactive glass

Titanium (Ti4+) containing materials have been widely used in medical applications due to its associated bioactivity in vivo. This study investigates the replacement of Si4+ with Ti4+ within the system SiO2-Na2O-CaO-P2O5 to determine its influence on glass structure. This strategy was conducted in o...

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Veröffentlicht in:Journal of biomedical materials research. Part B, Applied biomaterials Applied biomaterials, 2016-11, Vol.104 (8), p.1703-1712
Hauptverfasser: Placek, Lana M., Keenan, Timothy J., Li, Yiming, Yatongchai, Chokchai, Pradhan, Dimple, Boyd, Daniel, Mellott, Nathan P., Wren, Anthony W.
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Sprache:eng
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Zusammenfassung:Titanium (Ti4+) containing materials have been widely used in medical applications due to its associated bioactivity in vivo. This study investigates the replacement of Si4+ with Ti4+ within the system SiO2-Na2O-CaO-P2O5 to determine its influence on glass structure. This strategy was conducted in order to control the glass solubility to further improve the cellular response. Ti4+ incorporation was found to have little influence on the glass transition temperature (Tg=520±8°C) and magic angle spinning-nuclear magnetic resonance (MAS-NMR) shifts (-80 ppm) up to additions of 18 wt %. However, at 30 wt % the Tg increased to 600°C and MAS-NMR spectra shifted to -88 ppm. There was also an associated reduction in glass solubility as a function of Ti4+ incorporation as determined by inductively coupled plasma optical emission spectroscopy where Si4+ (1649-44 mg/L) and Na+ (892-36 mg/L) levels greatly reduced while Ca2+ (3-5 mg/L) and PO 4 3 - (2-7 mg/L) levels remained relatively unchanged. MC3T3 osteoblasts were used for cell culture testing and it was determined that the Ti4+ glasses increased cell viability and also facilitated greater osteoblast adhesion and proliferation to the glass surface compared to the control glass. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 1703-1712, 2016.
ISSN:1552-4973
1552-4981
DOI:10.1002/jbm.b.33521