Using α radiation to boost cancer immunity?
Radioimmunotherapy aims to deliver radiation directly to cancer cells by means of a tumor specific vector coupled to a radionuclide. Alpha radionuclides are very potent agents to treat disseminated cancer and metastasis. We have demonstrated that α radiation can also induce immunogenic cell death, r...
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| Veröffentlicht in: | Oncoimmunology 2014-10, Vol.3 (9), p.e954925-e954925 |
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| container_issue | 9 |
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| container_title | Oncoimmunology |
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| creator | Gorin, Jean-Baptiste Guilloux, Yannick Morgenstern, Alfred Chérel, Michel Davodeau, François Gaschet, Joëlle |
| description | Radioimmunotherapy aims to deliver radiation directly to cancer cells by means of a tumor specific vector coupled to a radionuclide. Alpha radionuclides are very potent agents to treat disseminated cancer and metastasis. We have demonstrated that α radiation can also induce immunogenic cell death, reinforcing interest in their clinical development. |
| doi_str_mv | 10.4161/21624011.2014.954925 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 2162-4011 |
| ispartof | Oncoimmunology, 2014-10, Vol.3 (9), p.e954925-e954925 |
| issn | 2162-4011 2162-402X 2162-402X |
| language | eng |
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| source | PubMed Central |
| subjects | abscopal effect Author's View Bi, bismuth-213 cancer DAMPs, danger associated molecular patterns DC, dendritic cells HMGB1, high mobility group box 1 Hsp70, 70 kilodalton heat shock protein immunogenic cell death ionizing radiation Ra, radium-224 RIT RIT, radioimmunotherapy α emitters |
| title | Using α radiation to boost cancer immunity? |
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