Using α radiation to boost cancer immunity?

Radioimmunotherapy aims to deliver radiation directly to cancer cells by means of a tumor specific vector coupled to a radionuclide. Alpha radionuclides are very potent agents to treat disseminated cancer and metastasis. We have demonstrated that α radiation can also induce immunogenic cell death, r...

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Veröffentlicht in:	Oncoimmunology 2014-10, Vol.3 (9), p.e954925-e954925
Hauptverfasser:	Gorin, Jean-Baptiste, Guilloux, Yannick, Morgenstern, Alfred, Chérel, Michel, Davodeau, François, Gaschet, Joëlle
Format:	Artikel
Sprache:	eng
Schlagworte:	abscopal effect Author's View Bi, bismuth-213 cancer DAMPs, danger associated molecular patterns DC, dendritic cells HMGB1, high mobility group box 1 Hsp70, 70 kilodalton heat shock protein immunogenic cell death ionizing radiation Ra, radium-224 RIT RIT, radioimmunotherapy α emitters
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Beschreibung
Zusammenfassung:	Radioimmunotherapy aims to deliver radiation directly to cancer cells by means of a tumor specific vector coupled to a radionuclide. Alpha radionuclides are very potent agents to treat disseminated cancer and metastasis. We have demonstrated that α radiation can also induce immunogenic cell death, reinforcing interest in their clinical development.
ISSN:	2162-4011 2162-402X 2162-402X
DOI:	10.4161/21624011.2014.954925