Targeting hypoxia at the forefront of anticancer immune responses

Hypoxia influences immune checkpoint receptors and their respective ligands. In support, we recently demonstrated that hypoxia selectively upregulates programmed cell death ligand 1 (PD-L1) on myeloid-derived suppressor cells (MDSCs) via hypoxia inducible factor 1 α (HIF-1α) binding to a hypoxia-res...

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Veröffentlicht in:Oncoimmunology 2014-12, Vol.3 (12), p.e954463-e954463
Hauptverfasser: Noman, Muhammad Zaeem, Chouaib, Salem
Format: Artikel
Sprache:eng
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Zusammenfassung:Hypoxia influences immune checkpoint receptors and their respective ligands. In support, we recently demonstrated that hypoxia selectively upregulates programmed cell death ligand 1 (PD-L1) on myeloid-derived suppressor cells (MDSCs) via hypoxia inducible factor 1 α (HIF-1α) binding to a hypoxia-response element (HRE) in the PD-L1 proximal promoter. Furthermore, blockade of PD-L1 under hypoxic conditions enhanced MDSC-mediated T-cell activation by attenuating MDSC secretion of IL-6 and IL-10.
ISSN:2162-4011
2162-402X
2162-402X
DOI:10.4161/21624011.2014.954463