CAR's made it to the pancreas

CAR's made it to the pancreas

Despite intensive treatment, pancreatic adenocarcinoma still has the worst prognosis among all malignancies. Using clinically relevant models, we demonstrated the therapeutic efficacy of adoptively transferred T cells engineered with a carcinoembryonic antigen (CEA)- and ERBB2-specific chimeric anti...

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Veröffentlicht in:Oncoimmunology 2012-11, Vol.1 (8), p.1387-1389
Hauptverfasser: Chmielewski, Markus, Maliar, Amit, Eshhar, Zelig, Abken, Hinrich
Format: Artikel
Sprache:eng
Schlagworte:
adoptive cell therapy
Binding
Biology
Bioscience
Calcium
Cancer
cancer stem cell
Cell
chimeric antigen receptor
Cycle
Landes
Organogenesis
pancreas adenocarcinoma
Point of View
Proteins
T cell
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Beschreibung
Zusammenfassung:Despite intensive treatment, pancreatic adenocarcinoma still has the worst prognosis among all malignancies. Using clinically relevant models, we demonstrated the therapeutic efficacy of adoptively transferred T cells engineered with a carcinoembryonic antigen (CEA)- and ERBB2-specific chimeric antigen receptor against pancreatic carcinoma. Targeting CD24, a putative cancer stem cell antigen expressed by a minority of carcinoma cells, was likewise effective.
ISSN:2162-4011
2162-402X
2162-402X
DOI:10.4161/onci.22195