Tumor immune escape in acute myeloid leukemia: Class II-associated invariant chain peptide expression as result of deficient antigen presentation

Tumor immune escape in acute myeloid leukemia: Class II-associated invariant chain peptide expression as result of deficient antigen presentation

In this overview, we discuss the role of class II-associated invariant chain peptide (CLIP) in acute myeloid leukemia (AML), one of the few tumors expressing HLA class II. The clinical impact, function and regulation of CLIP expression on leukemic cells is addressed, indicating its potential as immu...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Oncoimmunology 2012-03, Vol.1 (2), p.211-213
Hauptverfasser: van Luijn, Marvin M., Chamuleau, Martine E.D., Ossenkoppele, Gert J., van de Loosdrecht, Arjan A., Marieke van Ham, S.
Format: Artikel
Sprache:eng
Schlagworte:
Author's View
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cycle
human leukocyte antigen
immune surveillance
Landes
leukemic cell
major histocompatibility complex
Organogenesis
Proteins
T cell immunity
tumor immunogenicity
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:In this overview, we discuss the role of class II-associated invariant chain peptide (CLIP) in acute myeloid leukemia (AML), one of the few tumors expressing HLA class II. The clinical impact, function and regulation of CLIP expression on leukemic cells is addressed, indicating its potential as immunotherapeutic target in AML.
ISSN:2162-4011
2162-402X
2162-402X
DOI:10.4161/onci.1.2.18100