Calyculin A sensitive protein phosphatase is required for Bacillus anthracis lethal toxin induced cytotoxicity

Previous studies have shown that the Bacillus anthracis lethal toxin can induce both necrosis and apoptosis in mouse macrophage-like J774A.1 cells depending on both the toxin concentration and the phosphatase activity. In this study several protein kinase or phosphatase inhibitors were employed to e...

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Veröffentlicht in:	Current microbiology 2002-02, Vol.44 (2), p.106-111
Hauptverfasser:	KAU, Jyh-Hwa, LIN, Ching-Gong, HUANG, Hsin-Hsien, HSU, Hui-Ling, CHEN, Kuo-Ching, WU, Yu-Ping, LIN, Hung-Chi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthrax Antifungal Agents - pharmacology Antigens, Bacterial Apoptosis Bacillus anthracis Bacillus anthracis - enzymology Bacillus anthracis - metabolism Bacillus anthracis - pathogenicity Bacterial diseases Bacterial sepsis Bacterial Toxins - metabolism Bacterial Toxins - toxicity Bacteriology Biological and medical sciences Blotting, Western Cells, Cultured Cyclosporine - pharmacology Cytotoxicity Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Genistein - pharmacology Human bacterial diseases Infectious diseases Inhibitors Kinases MAP Kinase Kinase Kinase 1 Medical sciences MEK1 protein Metabolism. Enzymes Mice Microbiology Okadaic Acid - pharmacology Oxazoles - pharmacology Phosphoprotein Phosphatases - antagonists & inhibitors Phosphoprotein Phosphatases - metabolism Phosphorylation protein phosphatase Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - metabolism Proteins Pyrans Signal Transduction - drug effects Sphingosine - pharmacology Spiro Compounds Toxins
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