Hollow Structure Improved Anti-Cancer Immunity of Mesoporous Silica Nanospheres In Vivo

Hollow and non‐hollow mesoporous silica nanospheres are synthesized and used for cancer vaccine adjuvants. The hollow structure of mesoporous silica nanospheres significantly promote cellular uptake of a model cancer antigen by macrophage‐like cells in vitro, improve anti‐cancer immunity, CD4+ and C...

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Veröffentlicht in:	Small (Weinheim an der Bergstrasse, Germany) Germany), 2016-07, Vol.12 (26), p.3510-3515
Hauptverfasser:	Wang, Xiupeng, Li, Xia, Ito, Atsuo, Yoshiyuki, Kazuko, Sogo, Yu, Watanabe, Yohei, Yamazaki, Atsushi, Ohno, Tadao, Tsuji, Noriko M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants Adjuvants, Immunologic - adverse effects Adjuvants, Immunologic - chemistry Animals Antigens Cancer cancer immunoadjuvant Cancer Vaccines - administration & dosage Cancer Vaccines - chemistry Cell Survival - drug effects hollow structures Immunity mesoporous silica nanospheres Mice Microscopy, Electrochemical, Scanning Microscopy, Electron, Transmission Nanospheres Nanospheres - adverse effects Nanospheres - chemistry Nanospheres - ultrastructure Nanotechnology NIH 3T3 Cells Porosity Porous materials Silica Silicon dioxide Silicon Dioxide - chemistry Uptakes Vaccines
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Beschreibung
Zusammenfassung:	Hollow and non‐hollow mesoporous silica nanospheres are synthesized and used for cancer vaccine adjuvants. The hollow structure of mesoporous silica nanospheres significantly promote cellular uptake of a model cancer antigen by macrophage‐like cells in vitro, improve anti‐cancer immunity, CD4+ and CD8+ T cell populations in splenocytes of mice in vivo.
ISSN:	1613-6810 1613-6829
DOI:	10.1002/smll.201600677