Determination of glyphosate and its metabolite in emergency room in Korea

Determination of glyphosate and its metabolite in emergency room in Korea

Highlights • A fast method to determine the concentration of glyphosate without derivatization is established by LC–MS/MS. • The concentration of glyphosate and its metabolite from blood samples of intoxicated patients in emergency room is measured. • The blood concentrations and clinical symptoms a...

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Veröffentlicht in:Forensic science international 2016-08, Vol.265, p.41-46
Hauptverfasser: Han, Joseph, Moon, Hantae, Hong, Youngki, Yang, Songhee, Jeong, Won-joon, Lee, Kwang-Sik, Chung, Heesun
Format: Artikel
Sprache:eng
Schlagworte:
Accuracy
Aged
Aged, 80 and over
Antibiotics
Blood
Blood concentration
Chromatography, Liquid
Clinical symptoms
Correlation
Diagnosis, Differential
Emergencies
Emergency medical care
Emergency medical services
Female
Forensic sciences
Gas Chromatography-Mass Spectrometry
Glycine - analogs & derivatives
Glycine - blood
Glyphosate
Humans
Intoxicated patients
Intoxication
Limit of Detection
Liquid chromatography
Male
Metabolism
Metabolite
Metabolites
Middle Aged
Molecular weight
Paraquat
Paraquat - poisoning
Pathology
Patients
Pneumonia
Reproducibility of Results
Republic of Korea
Respiratory distress syndrome
Studies
Substance-Related Disorders - diagnosis
Suicides & suicide attempts
Tandem mass spectrometry
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Zusammenfassung:Highlights • A fast method to determine the concentration of glyphosate without derivatization is established by LC–MS/MS. • The concentration of glyphosate and its metabolite from blood samples of intoxicated patients in emergency room is measured. • The blood concentrations and clinical symptoms are not well correlated, possibly indicating effects of surfactants. • The system that determines the blood concentration in advance can predict complications, which assists treatment.
ISSN:0379-0738
1872-6283
DOI:10.1016/j.forsciint.2015.12.049