A spiropyran-based fluorescent probe for the specific detection of β-amyloid peptide oligomers in Alzheimer's disease

We report a new spiropyran-based fluorescent probe that exhibits high affinity and specificity towards Aβ oligomers both in vitro and in vivo . This probe can penetrate the blood brain barrier and specifically target Aβ oligomers in the brains of transgenic mice in models for Alzheimer's diseas...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2016-07, Vol.52 (57), p.8865-8868
Hauptverfasser:	Lv, Guanglei, Sun, Anyang, Wei, Peng, Zhang, Ning, Lan, Haichuang, Yi, Tao
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Alzheimer Disease - diagnosis Alzheimer's disease Amyloid beta-Peptides - analysis Animals Barriers Benzopyrans - administration & dosage Benzopyrans - chemistry Blood Brain Disease Models, Animal Fluorescence Fluorescent Dyes - administration & dosage Fluorescent Dyes - chemistry Indoles - administration & dosage Indoles - chemistry Injections, Intraperitoneal Mice Mice, Transgenic Molecular Structure Nitro Compounds - administration & dosage Nitro Compounds - chemistry Oligomers Quantum Theory Transgenic
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Beschreibung
Zusammenfassung:	We report a new spiropyran-based fluorescent probe that exhibits high affinity and specificity towards Aβ oligomers both in vitro and in vivo . This probe can penetrate the blood brain barrier and specifically target Aβ oligomers in the brains of transgenic mice in models for Alzheimer's disease. A fluorescent probe for the specific detection of Aβ oligomers in Alzheimer's disease both in vitro and in vivo was developed.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c6cc02741e