Hypoxia-induced enrichment and mutagenesis of cells that have lost DNA mismatch repair

Loss of DNA mismatch repair (MMR) increases the risk of spontaneous mutations. We sought to determine whether there was an interaction between hypoxia and MMR deficiency that might contribute to the phenomenon of tumor progression. Human colon carcinoma HCT116+ch2 (MMR-deficient) and HCT116+ch3 (MMR...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2001-10, Vol.61 (20), p.7603-7607
Hauptverfasser:	KONDO, Akira, SAFAEI, Roohangiz, MISHIMA, Misako, NIEDNER, Hannes, XINJIAN LIN, HOWELL, Stephen B
Format:	Artikel
Sprache:	eng
Schlagworte:	6-thioguanine Adenocarcinoma - genetics Adenocarcinoma - metabolism Base Pair Mismatch - genetics Biological and medical sciences Cell Hypoxia - genetics Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism DNA Repair Fundamental and applied biological sciences. Psychology Humans Hydrogen-Ion Concentration Microsatellite Repeats - genetics mismatch repair Molecular and cellular biology Mutagenesis - genetics Mutagenesis - physiology Tumor Cells, Cultured
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Zusammenfassung:	Loss of DNA mismatch repair (MMR) increases the risk of spontaneous mutations. We sought to determine whether there was an interaction between hypoxia and MMR deficiency that might contribute to the phenomenon of tumor progression. Human colon carcinoma HCT116+ch2 (MMR-deficient) and HCT116+ch3 (MMR-proficient) sublines were exposed for varying periods of time to an environment of
ISSN:	0008-5472 1538-7445