Novel dual agonist peptide analogues derived from dogfish glucagon show promising in vitro insulin releasing actions and antihyperglycaemic activity in mice

The antidiabetic potential of thirteen novel dogfish glucagon derived analogues were assessed in vitro and in acute in vivo studies. Stable peptide analogues enhanced insulin secretion from BRIN-BD11 β-cells (p

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Bibliographische Detailangaben
Veröffentlicht in:	Molecular and cellular endocrinology 2016-08, Vol.431, p.133-144
Hauptverfasser:	O'Harte, F.P.M., Ng, M.T., Lynch, A.M., Conlon, J.M., Flatt, P.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute effects Animals Antidiabetic and antihyperglycaemic Cell Line Cricetinae Diabetes Dogfish Dogfish - metabolism Dogfish glucagon Dual agonist Gastric Inhibitory Polypeptide - metabolism Glucagon Glucagon - metabolism Glucagon-Like Peptide 1 - metabolism Glucagon-like peptide-1 (GLP-1) Glucose Glucose - metabolism Glucose dependent insulinotropic polypeptide (GIP) HEK293 Cells Humans Hypoglycemic Agents - pharmacology In vitro testing In vivo methods and tests Insulin Insulin - metabolism Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Peptides Peptides - pharmacology Receptors Receptors, Gastrointestinal Hormone - metabolism Receptors, Glucagon - metabolism
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Beschreibung
Zusammenfassung:	The antidiabetic potential of thirteen novel dogfish glucagon derived analogues were assessed in vitro and in acute in vivo studies. Stable peptide analogues enhanced insulin secretion from BRIN-BD11 β-cells (p
ISSN:	0303-7207 1872-8057
DOI:	10.1016/j.mce.2016.05.012