Determination of an optimal control strategy for drug administration in tumor treatment using multi-objective optimization differential evolution
Highlights • To formulate and to solve a multiobjective optimal control problem applied to treatment of tumors. • Objectives: to minimize the cancerous cells concentration and the drug concentration. • The results demonstrated that an optimal protocol can be obtained considering both the objectives....
Gespeichert in:
| Veröffentlicht in: | Computer methods and programs in biomedicine 2016-07, Vol.131, p.51-61 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 61 |
|---|---|
| container_issue | |
| container_start_page | 51 |
| container_title | Computer methods and programs in biomedicine |
| container_volume | 131 |
| creator | Lobato, Fran Sérgio Machado, Vinicius Silvério Steffen, Valder |
| description | Highlights • To formulate and to solve a multiobjective optimal control problem applied to treatment of tumors. • Objectives: to minimize the cancerous cells concentration and the drug concentration. • The results demonstrated that an optimal protocol can be obtained considering both the objectives. |
| doi_str_mv | 10.1016/j.cmpb.2016.04.004 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1825541405</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0169260715304600</els_id><sourcerecordid>1794470099</sourcerecordid><originalsourceid>FETCH-LOGICAL-c477t-7011c33b9fdaad500dcd35b2bd596398d7fbc26ea8dadee2d48e5adfe0da369f3</originalsourceid><addsrcrecordid>eNqNksGK1TAUhosozp3RF3AhXbppPUmTpgURZNRRGHChrkOanFxybZtrkl64voVvbGpHFy7UTRLO-f8_cL5TFE8I1ARI-_xQ6-k41DS_a2A1ALtX7EgnaCV4y-8Xu9zoK9qCuCguYzwAAOW8fVhcUEFbDqzbFd9fY8IwuVkl5-fS21Ll85jcpMZS-zkFP5YxBZVwfy6tD6UJy75UJlvcz_pqc3OZlik3U0CVJpxTuUQ378tpGZOr_HBAndwJt2T3bXMZZy2GLHb5Lzz5cVnLj4oHVo0RH9_dV8Xnt28-Xb-rbj_cvL9-dVtpJkSqBBCim2borVHKcACjTcMHOhjet03fGWEHTVtUnVEGkRrWIVfGIhjVtL1tropnW-4x-K8LxiQnFzWOo5rRL1GSLg-LEQb8P6TQCegZNP-Wip4xAdD3WUo3qQ4-xoBWHkMeezhLAnIFLA9yBSxXwBKYzICz6eld_jJMaH5bfhHNghebAPPsTg6DjNrhrNG4kCFI493f81_-YddjJq3V-AXPGA9-CXOmIomMVIL8uK7YumGEN8BagOYHeNHQ_g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1794470099</pqid></control><display><type>article</type><title>Determination of an optimal control strategy for drug administration in tumor treatment using multi-objective optimization differential evolution</title><source>Elsevier ScienceDirect Journals Complete - AutoHoldings</source><source>MEDLINE</source><creator>Lobato, Fran Sérgio ; Machado, Vinicius Silvério ; Steffen, Valder</creator><creatorcontrib>Lobato, Fran Sérgio ; Machado, Vinicius Silvério ; Steffen, Valder</creatorcontrib><description>Highlights • To formulate and to solve a multiobjective optimal control problem applied to treatment of tumors. • Objectives: to minimize the cancerous cells concentration and the drug concentration. • The results demonstrated that an optimal protocol can be obtained considering both the objectives.</description><identifier>ISSN: 0169-2607</identifier><identifier>EISSN: 1872-7565</identifier><identifier>DOI: 10.1016/j.cmpb.2016.04.004</identifier><identifier>PMID: 27265048</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Algorithms ; Antineoplastic Agents - administration & dosage ; Antineoplastic Agents - therapeutic use ; Cell Proliferation ; Computer Simulation ; Differential evolution algorithm ; Drugs ; Dynamics ; Humans ; Internal Medicine ; Mathematical modeling of tumors ; Mathematical models ; Multi-objective optimization ; Neoplasms - drug therapy ; Neoplasms - pathology ; Optimal control problem ; Optimization ; Other ; Patients ; Strategy ; Tumors</subject><ispartof>Computer methods and programs in biomedicine, 2016-07, Vol.131, p.51-61</ispartof><rights>2016 Elsevier Ireland Ltd</rights><rights>Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-7011c33b9fdaad500dcd35b2bd596398d7fbc26ea8dadee2d48e5adfe0da369f3</citedby><cites>FETCH-LOGICAL-c477t-7011c33b9fdaad500dcd35b2bd596398d7fbc26ea8dadee2d48e5adfe0da369f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cmpb.2016.04.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27265048$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lobato, Fran Sérgio</creatorcontrib><creatorcontrib>Machado, Vinicius Silvério</creatorcontrib><creatorcontrib>Steffen, Valder</creatorcontrib><title>Determination of an optimal control strategy for drug administration in tumor treatment using multi-objective optimization differential evolution</title><title>Computer methods and programs in biomedicine</title><addtitle>Comput Methods Programs Biomed</addtitle><description>Highlights • To formulate and to solve a multiobjective optimal control problem applied to treatment of tumors. • Objectives: to minimize the cancerous cells concentration and the drug concentration. • The results demonstrated that an optimal protocol can be obtained considering both the objectives.</description><subject>Algorithms</subject><subject>Antineoplastic Agents - administration & dosage</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Cell Proliferation</subject><subject>Computer Simulation</subject><subject>Differential evolution algorithm</subject><subject>Drugs</subject><subject>Dynamics</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Mathematical modeling of tumors</subject><subject>Mathematical models</subject><subject>Multi-objective optimization</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - pathology</subject><subject>Optimal control problem</subject><subject>Optimization</subject><subject>Other</subject><subject>Patients</subject><subject>Strategy</subject><subject>Tumors</subject><issn>0169-2607</issn><issn>1872-7565</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNksGK1TAUhosozp3RF3AhXbppPUmTpgURZNRRGHChrkOanFxybZtrkl64voVvbGpHFy7UTRLO-f8_cL5TFE8I1ARI-_xQ6-k41DS_a2A1ALtX7EgnaCV4y-8Xu9zoK9qCuCguYzwAAOW8fVhcUEFbDqzbFd9fY8IwuVkl5-fS21Ll85jcpMZS-zkFP5YxBZVwfy6tD6UJy75UJlvcz_pqc3OZlik3U0CVJpxTuUQ378tpGZOr_HBAndwJt2T3bXMZZy2GLHb5Lzz5cVnLj4oHVo0RH9_dV8Xnt28-Xb-rbj_cvL9-dVtpJkSqBBCim2borVHKcACjTcMHOhjet03fGWEHTVtUnVEGkRrWIVfGIhjVtL1tropnW-4x-K8LxiQnFzWOo5rRL1GSLg-LEQb8P6TQCegZNP-Wip4xAdD3WUo3qQ4-xoBWHkMeezhLAnIFLA9yBSxXwBKYzICz6eld_jJMaH5bfhHNghebAPPsTg6DjNrhrNG4kCFI493f81_-YddjJq3V-AXPGA9-CXOmIomMVIL8uK7YumGEN8BagOYHeNHQ_g</recordid><startdate>20160701</startdate><enddate>20160701</enddate><creator>Lobato, Fran Sérgio</creator><creator>Machado, Vinicius Silvério</creator><creator>Steffen, Valder</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SC</scope><scope>JQ2</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope></search><sort><creationdate>20160701</creationdate><title>Determination of an optimal control strategy for drug administration in tumor treatment using multi-objective optimization differential evolution</title><author>Lobato, Fran Sérgio ; Machado, Vinicius Silvério ; Steffen, Valder</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-7011c33b9fdaad500dcd35b2bd596398d7fbc26ea8dadee2d48e5adfe0da369f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Algorithms</topic><topic>Antineoplastic Agents - administration & dosage</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Cell Proliferation</topic><topic>Computer Simulation</topic><topic>Differential evolution algorithm</topic><topic>Drugs</topic><topic>Dynamics</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Mathematical modeling of tumors</topic><topic>Mathematical models</topic><topic>Multi-objective optimization</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - pathology</topic><topic>Optimal control problem</topic><topic>Optimization</topic><topic>Other</topic><topic>Patients</topic><topic>Strategy</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lobato, Fran Sérgio</creatorcontrib><creatorcontrib>Machado, Vinicius Silvério</creatorcontrib><creatorcontrib>Steffen, Valder</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>ProQuest Computer Science Collection</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><jtitle>Computer methods and programs in biomedicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lobato, Fran Sérgio</au><au>Machado, Vinicius Silvério</au><au>Steffen, Valder</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of an optimal control strategy for drug administration in tumor treatment using multi-objective optimization differential evolution</atitle><jtitle>Computer methods and programs in biomedicine</jtitle><addtitle>Comput Methods Programs Biomed</addtitle><date>2016-07-01</date><risdate>2016</risdate><volume>131</volume><spage>51</spage><epage>61</epage><pages>51-61</pages><issn>0169-2607</issn><eissn>1872-7565</eissn><abstract>Highlights • To formulate and to solve a multiobjective optimal control problem applied to treatment of tumors. • Objectives: to minimize the cancerous cells concentration and the drug concentration. • The results demonstrated that an optimal protocol can be obtained considering both the objectives.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>27265048</pmid><doi>10.1016/j.cmpb.2016.04.004</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0169-2607 |
| ispartof | Computer methods and programs in biomedicine, 2016-07, Vol.131, p.51-61 |
| issn | 0169-2607 1872-7565 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1825541405 |
| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Algorithms Antineoplastic Agents - administration & dosage Antineoplastic Agents - therapeutic use Cell Proliferation Computer Simulation Differential evolution algorithm Drugs Dynamics Humans Internal Medicine Mathematical modeling of tumors Mathematical models Multi-objective optimization Neoplasms - drug therapy Neoplasms - pathology Optimal control problem Optimization Other Patients Strategy Tumors |
| title | Determination of an optimal control strategy for drug administration in tumor treatment using multi-objective optimization differential evolution |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T16%3A37%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Determination%20of%20an%20optimal%20control%20strategy%20for%20drug%20administration%20in%20tumor%20treatment%20using%20multi-objective%20optimization%20differential%20evolution&rft.jtitle=Computer%20methods%20and%20programs%20in%20biomedicine&rft.au=Lobato,%20Fran%20S%C3%A9rgio&rft.date=2016-07-01&rft.volume=131&rft.spage=51&rft.epage=61&rft.pages=51-61&rft.issn=0169-2607&rft.eissn=1872-7565&rft_id=info:doi/10.1016/j.cmpb.2016.04.004&rft_dat=%3Cproquest_cross%3E1794470099%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1794470099&rft_id=info:pmid/27265048&rft_els_id=S0169260715304600&rfr_iscdi=true |