Determination of an optimal control strategy for drug administration in tumor treatment using multi-objective optimization differential evolution

Highlights • To formulate and to solve a multiobjective optimal control problem applied to treatment of tumors. • Objectives: to minimize the cancerous cells concentration and the drug concentration. • The results demonstrated that an optimal protocol can be obtained considering both the objectives....

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Veröffentlicht in:	Computer methods and programs in biomedicine 2016-07, Vol.131, p.51-61
Hauptverfasser:	Lobato, Fran Sérgio, Machado, Vinicius Silvério, Steffen, Valder
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Antineoplastic Agents - administration & dosage Antineoplastic Agents - therapeutic use Cell Proliferation Computer Simulation Differential evolution algorithm Drugs Dynamics Humans Internal Medicine Mathematical modeling of tumors Mathematical models Multi-objective optimization Neoplasms - drug therapy Neoplasms - pathology Optimal control problem Optimization Other Patients Strategy Tumors
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Beschreibung
Zusammenfassung:	Highlights • To formulate and to solve a multiobjective optimal control problem applied to treatment of tumors. • Objectives: to minimize the cancerous cells concentration and the drug concentration. • The results demonstrated that an optimal protocol can be obtained considering both the objectives.
ISSN:	0169-2607 1872-7565
DOI:	10.1016/j.cmpb.2016.04.004