Nickel-catalyzed enantioselective arylation of pyridine
We report an enantioselective Ni-catalyzed cross coupling of arylzinc reagents with pyridinium ions formed in situ from pyridine and a chloroformate. This reaction provides enantioenriched 2-aryl-1,2-dihydropyridine products that can be elaborated to numerous piperidine derivatives with little or no...
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Veröffentlicht in: | Chemical science (Cambridge) 2016-01, Vol.7 (7), p.415-419 |
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Hauptverfasser: | , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | We report an enantioselective Ni-catalyzed cross coupling of arylzinc reagents with pyridinium ions formed
in situ
from pyridine and a chloroformate. This reaction provides enantioenriched 2-aryl-1,2-dihydropyridine products that can be elaborated to numerous piperidine derivatives with little or no loss in ee. This method is notable for its use of pyridine, a feedstock chemical, to build a versatile, chiral heterocycle in a single synthetic step.
A Ni-catalyzed cross coupling of arylzinc reagents with pyridinium ions provides enantioenriched dihydropyridines, which are precursors to diverse piperidine derivatives. |
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ISSN: | 2041-6520 2041-6539 |
DOI: | 10.1039/c6sc00702c |