Synthesis of 1,2,3,4-tetrasubstituted naphthalenes through a cascade reaction triggered by silyl acetal activation

Synthesis of 1,2,3,4-tetrasubstituted naphthalenes through a cascade reaction triggered by silyl acetal activation

1,2,3,4-Tetrasubstituted naphthalenes bearing four different substituents were synthesized in a regioselective manner through a fluoride-induced cascade reaction of lactol silyl ethers, which could be easily prepared from 4-alkynylisocoumarins and ketene silyl acetal.

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (51), p.7974-7977
Hauptverfasser: Yanai, Hikaru, Ishii, Nobuyuki, Matsumoto, Takashi
Format: Artikel
Sprache:eng
Schlagworte:
Activation
Bearing
Cascade chemical reactions
Ethers
Ketenes
Synthesis (chemistry)
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Zusammenfassung:1,2,3,4-Tetrasubstituted naphthalenes bearing four different substituents were synthesized in a regioselective manner through a fluoride-induced cascade reaction of lactol silyl ethers, which could be easily prepared from 4-alkynylisocoumarins and ketene silyl acetal.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc03510h