Pharmaceutical crystalline complexes of sulfamethazine with saccharin: same interaction site but different ionization states

Sulfamethazine (SMT), a widely used antibacterial drug, can form either a 1 : 1 salt or a 1 : 1 cocrystal with saccharin (SAC), an artificial sweetener. Interestingly, the two crystalline complexes possess the same main intermolecular interaction sites, except the locations of the acidic proton are different. Sulfamethazine (SMT) can form either 1 : 1 salt or 1 : 1 cocrystal with saccharin (SAC). The two crystalline complexes possess the same main intermolecular interaction site except the locations of the acidic proton are different.