Dearomatization of Indole Derivatives via Palladium-Catalyzed CH Bond Functionalization of Pyrroles: Convenient Construction of Spiroindolenines

Dearomatization of Indole Derivatives via Palladium-Catalyzed CH Bond Functionalization of Pyrroles: Convenient Construction of Spiroindolenines

An intramolecular palladium(II)‐catalyzed dearomative arylation reaction of indoles via CH bond functionalization was developed, providing access to structurally novel spiroindolenines with moderate to good yields. A one‐pot process for the synthesis of spiroindoline derivatives was also realized....

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Veröffentlicht in:Advanced synthesis & catalysis 2016-06, Vol.358 (12), p.1892-1896
Hauptverfasser: Lei, Xiantao, Xie, Hong-Yan, Xu, Chang, Liu, Xiaoyu, Wen, Xiaoan, Sun, Hongbin, Xu, Qing-Long
Format: Artikel
Sprache:eng
Schlagworte:
arylation
Bonding
Catalysis
Construction
CH bond functionalization
dearomatization
Derivatives
Indoles
palladium(ii)-catalyzed reaction
Pyrroles
Synthesis
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Zusammenfassung:An intramolecular palladium(II)‐catalyzed dearomative arylation reaction of indoles via CH bond functionalization was developed, providing access to structurally novel spiroindolenines with moderate to good yields. A one‐pot process for the synthesis of spiroindoline derivatives was also realized.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201600135