A synthesized butyrolactone derivative in combination with chloroquine can inhibit cancer cell growth and lysosome vacuolation induced by chloroquine in A549 lung cancer cells

A synthesized butyrolactone derivative in combination with chloroquine can inhibit cancer cell growth and lysosome vacuolation induced by chloroquine in A549 lung cancer cells

3BDO in combination with chloroquine could elevate the Na + ,K + -ATPase activity and decrease the expression of long non-coding RNA TGFB2-OT1 . Therefore, the combination inhibited the cell growth and lysosomal vacuolation. 3BDO in combination with chloroquine could elevate the Na + ,K + -ATPase ac...

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Veröffentlicht in:RSC advances 2016-01, Vol.6 (59), p.5499-5411
Hauptverfasser: Chen, Xin-Peng, Fan, Chuan-Dong, Su, Le, Zhao, Bao-Xiang, Miao, Jun-Ying
Format: Artikel
Sprache:eng
Schlagworte:
Butyrolactone
Cancer
Derivatives
Gene expression
Lungs
Lysosomes
Ribonucleic acids
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Zusammenfassung:3BDO in combination with chloroquine could elevate the Na + ,K + -ATPase activity and decrease the expression of long non-coding RNA TGFB2-OT1 . Therefore, the combination inhibited the cell growth and lysosomal vacuolation. 3BDO in combination with chloroquine could elevate the Na + ,K + -ATPase activity and decrease the expression of competing endogenous non-coding RNA TGFB2-OT1 . Therefore, ​ the combination inhibited the cells growth and lysosomal vacuolation induced by CQ.
ISSN:2046-2069
2046-2069
DOI:10.1039/c6ra02533a