Rapid Discrimination of Polymorphic Crystal Forms by Nonlinear Optical Stokes Ellipsometric Microscopy

Rapid Discrimination of Polymorphic Crystal Forms by Nonlinear Optical Stokes Ellipsometric Microscopy

The use of nonlinear optical Stokes ellipsometric (NOSE) microscopy for rapid discrimination of two polymorphic forms of the small molecule d-mannitol is presented. Fast (8 MHz) polarization modulated beam-scanning microscopy and a recently developed iterative, nonlinear least-squares fitting algori...

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Veröffentlicht in:Analytical chemistry (Washington) 2016-06, Vol.88 (11), p.5760-5768
Hauptverfasser: Schmitt, Paul D, DeWalt, Emma L, Dow, Ximeng Y, Simpson, Garth J
Format: Artikel
Sprache:eng
Schlagworte:
Algorithms
Analytical chemistry
Crystal structure
Discriminant analysis
Discrimination
Ellipsometry
Fittings
Fluid flow
Microscopy
Molecules
Nonlinearity
Nose
Signal to noise ratio
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Zusammenfassung:The use of nonlinear optical Stokes ellipsometric (NOSE) microscopy for rapid discrimination of two polymorphic forms of the small molecule d-mannitol is presented. Fast (8 MHz) polarization modulated beam-scanning microscopy and a recently developed iterative, nonlinear least-squares fitting algorithm were combined to allow discrimination of orthorhombic and monoclinic crystal structures of d-mannitol with data acquisition times of
ISSN:0003-2700
1520-6882
DOI:10.1021/acs.analchem.6b00057