The polymer physics of single DNA confined in nanochannels

In recent years, applications and experimental studies of DNA in nanochannels have stimulated the investigation of the polymer physics of DNA in confinement. Recent advances in the physics of confined polymers, using DNA as a model polymer, have moved beyond the classic Odijk theory for the strong confinement, and the classic blob theory for the weak confinement. In this review, we present the current understanding of the behaviors of confined polymers while briefly reviewing classic theories. Three aspects of confined DNA are presented: static, dynamic, and topological properties. The relevant simulation methods are also summarized. In addition, comparisons of confined DNA with DNA under tension and DNA in semidilute solution are made to emphasize universal behaviors. Finally, an outlook of the possible future research for confined DNA is given. [Display omitted] •This review systematically presents the recent progress in polymer physics of DNA in nanochannels•This review highlights the similarities among polymers in confinement, under stretching force, and in semidilute solution.•This review describes the connection between polymer behaviors in confinement and under topological constraints (knots).