Oxoethylene derivative of the natural substrate as an inhibitor of matrix metalloproteinase MMP-2

Oxoethylene derivative of the natural substrate as an inhibitor of matrix metalloproteinase MMP-2

[Display omitted] A mimetic of a natural substrate of the matrix metalloproteinase MMP-2, in which the amide group with the scissile peptide bond is replaced with the oxoethylene moiety, inhibits the enzyme.

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Bibliographische Detailangaben
Veröffentlicht in:Mendeleev communications 2016-05, Vol.26 (3), p.207-208
Hauptverfasser: Khrenova, Maria G., Solovyev, Ilya D., Azev, Viatcheslav N., Lapshin, Grigory D., Savitsky, Alexander P.
Format: Artikel
Sprache:eng
Schlagworte:
Amides
Bonding
Derivatives
Enzymes
Inhibitors
Matrix metalloproteinases
Substrate inhibition
Substrates
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Beschreibung
Zusammenfassung:[Display omitted] A mimetic of a natural substrate of the matrix metalloproteinase MMP-2, in which the amide group with the scissile peptide bond is replaced with the oxoethylene moiety, inhibits the enzyme.
ISSN:0959-9436
DOI:10.1016/j.mencom.2016.04.009