Directed Assembly and Development of Material-Free Tissues with Complex Architectures

Material‐free tissues are assembled using solely cells. Microstructured hydrogel templates and high content screening allow the formation of centimeter‐scale tissues with precise architectures. Similar to developing tissues, these contract autonomously, controllably shift shape, self‐scaffold by sec...

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Veröffentlicht in:	Advanced materials (Weinheim) 2016-06, Vol.28 (21), p.4032-4039
Hauptverfasser:	Vrij, Erik, Rouwkema, Jeroen, LaPointe, Vanessa, van Blitterswijk, Clemens, Truckenmüller, Roman, Rivron, Nicolas
Format:	Artikel
Sprache:	eng
Schlagworte:	Architecture Assembly bottom-up tissue engineering cellular building blocks Contracts directed development Extracellular Matrix Formations high-throughput screening Hydrogels Screening Tissue Engineering tissues
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creator	Vrij, Erik Rouwkema, Jeroen LaPointe, Vanessa van Blitterswijk, Clemens Truckenmüller, Roman Rivron, Nicolas
description	Material‐free tissues are assembled using solely cells. Microstructured hydrogel templates and high content screening allow the formation of centimeter‐scale tissues with precise architectures. Similar to developing tissues, these contract autonomously, controllably shift shape, self‐scaffold by secreting extracellular matrix, and undergo morphogenesis.
doi_str_mv	10.1002/adma.201505723
format	Article
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subjects	Architecture Assembly bottom-up tissue engineering cellular building blocks Contracts directed development Extracellular Matrix Formations high-throughput screening Hydrogels Screening Tissue Engineering tissues
title	Directed Assembly and Development of Material-Free Tissues with Complex Architectures
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