Directed Assembly and Development of Material-Free Tissues with Complex Architectures

Directed Assembly and Development of Material-Free Tissues with Complex Architectures

Material‐free tissues are assembled using solely cells. Microstructured hydrogel templates and high content screening allow the formation of centimeter‐scale tissues with precise architectures. Similar to developing tissues, these contract autonomously, controllably shift shape, self‐scaffold by sec...

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Veröffentlicht in:Advanced materials (Weinheim) 2016-06, Vol.28 (21), p.4032-4039
Hauptverfasser: Vrij, Erik, Rouwkema, Jeroen, LaPointe, Vanessa, van Blitterswijk, Clemens, Truckenmüller, Roman, Rivron, Nicolas
Format: Artikel
Sprache:eng
Schlagworte:
Architecture
Assembly
bottom-up tissue engineering
cellular building blocks
Contracts
directed development
Extracellular Matrix
Formations
high-throughput screening
Hydrogels
Screening
Tissue Engineering
tissues
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Beschreibung
Zusammenfassung:Material‐free tissues are assembled using solely cells. Microstructured hydrogel templates and high content screening allow the formation of centimeter‐scale tissues with precise architectures. Similar to developing tissues, these contract autonomously, controllably shift shape, self‐scaffold by secreting extracellular matrix, and undergo morphogenesis.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201505723