Antidiabetic and Antihyperlipidemic Effects of Ethanol Extract of Rosa canina L. fruit on Diabetic Rats: An Experimental Study With Histopathological Evaluations
Rosa canina L. (Rosaceae) has been traditionally used as a medicinal plant. This study was undertaken to evaluate the antidiabetic and antihyperlipidemic effects of Rosa canina fruit extract in streptozotocin induced diabetic rats. The results showed oral administration of Rosa canina fruit extract...
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| Veröffentlicht in: | Journal of evidence-based complementary & alternative medicine 2016-10, Vol.21 (4), p.NP25-NP30 |
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| container_end_page | NP30 |
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| container_issue | 4 |
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| container_title | Journal of evidence-based complementary & alternative medicine |
| container_volume | 21 |
| creator | Taghizadeh, Mohsen Rashidi, Ali Akbar Taherian, Ali Akbar Vakili, Zarichehr Sajad Sajadian, Mohammad Ghardashi, Mostafa |
| description | Rosa canina L. (Rosaceae) has been traditionally used as a medicinal plant. This study was undertaken to evaluate the antidiabetic and antihyperlipidemic effects of Rosa canina fruit extract in streptozotocin induced diabetic rats. The results showed oral administration of Rosa canina fruit extract significantly ameliorated the high levels of blood glucose compared with the control group. Serum triglyceride levels significantly decreased by the administration of Rosa canina extract compared with control. Histopathological examinations showed that the Rosa canina extract improved islets necrotic and regenerated pancreatic islet cells. Rosa canina extract has the antihyperglycemic and antihyperlipidemic effects in streptozotocin-induced diabetic rats. |
| doi_str_mv | 10.1177/2156587215612626 |
| format | Article |
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(Rosaceae) has been traditionally used as a medicinal plant. This study was undertaken to evaluate the antidiabetic and antihyperlipidemic effects of Rosa canina fruit extract in streptozotocin induced diabetic rats. The results showed oral administration of Rosa canina fruit extract significantly ameliorated the high levels of blood glucose compared with the control group. Serum triglyceride levels significantly decreased by the administration of Rosa canina extract compared with control. Histopathological examinations showed that the Rosa canina extract improved islets necrotic and regenerated pancreatic islet cells. Rosa canina extract has the antihyperglycemic and antihyperlipidemic effects in streptozotocin-induced diabetic rats.</description><subject>Animals</subject><subject>Blood Glucose - drug effects</subject><subject>Diabetes Mellitus, Experimental - metabolism</subject><subject>Fruit - chemistry</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Hypolipidemic Agents - pharmacology</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Pancreas - drug effects</subject><subject>Pancreas - pathology</subject><subject>Plant Extracts - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rosa - chemistry</subject><issn>2156-5872</issn><issn>2156-5899</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UMtqwzAQFKWlCWnuPRUde3EqybYkH0PqPiBQCO3ZyLKUKPhVSYbm7yuTx6HQvcwwzA67A8A9RguMGXsiOKUpZyNgQgm9AtORRynPsusLZ2QC5s7tUZgkJQnNbsGE0CTjCedTsF223lRGlMobCUVbwVHYHXpla9ObSjVBzrVW0jvYaZj7nWi7GuY_3grpR2nTOQGlaE0r4HoBtR1M0Fv4fE7dCO_uwI0WtVPzE87A10v-uXqL1h-v76vlOpIkQz7KKCKslJUqUZVwShnDjJZZijVjIlBKZVyWFCFOCNUxrmSMNU44QuFEQap4Bh6Pub3tvgflfNEYJ1Vdi1Z1gyswJykhiKdxsKKjVdrOOat00VvTCHsoMCrGhou_DYeVh1P6UDaquiyc-wyG6GhwYquKfTfYNnz7f-AvHgCBpg</recordid><startdate>201610</startdate><enddate>201610</enddate><creator>Taghizadeh, Mohsen</creator><creator>Rashidi, Ali Akbar</creator><creator>Taherian, Ali Akbar</creator><creator>Vakili, Zarichehr</creator><creator>Sajad Sajadian, Mohammad</creator><creator>Ghardashi, Mostafa</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201610</creationdate><title>Antidiabetic and Antihyperlipidemic Effects of Ethanol Extract of Rosa canina L. fruit on Diabetic Rats</title><author>Taghizadeh, Mohsen ; Rashidi, Ali Akbar ; Taherian, Ali Akbar ; Vakili, Zarichehr ; Sajad Sajadian, Mohammad ; Ghardashi, Mostafa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c290t-96027bcdeb0d486677176b951f77a17666c3bb6008226f31dc31f14800ffea2d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Blood Glucose - drug effects</topic><topic>Diabetes Mellitus, Experimental - metabolism</topic><topic>Fruit - chemistry</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Hypolipidemic Agents - pharmacology</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Pancreas - drug effects</topic><topic>Pancreas - pathology</topic><topic>Plant Extracts - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rosa - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Taghizadeh, Mohsen</creatorcontrib><creatorcontrib>Rashidi, Ali Akbar</creatorcontrib><creatorcontrib>Taherian, Ali Akbar</creatorcontrib><creatorcontrib>Vakili, Zarichehr</creatorcontrib><creatorcontrib>Sajad Sajadian, Mohammad</creatorcontrib><creatorcontrib>Ghardashi, Mostafa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of evidence-based complementary & alternative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Taghizadeh, Mohsen</au><au>Rashidi, Ali Akbar</au><au>Taherian, Ali Akbar</au><au>Vakili, Zarichehr</au><au>Sajad Sajadian, Mohammad</au><au>Ghardashi, Mostafa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antidiabetic and Antihyperlipidemic Effects of Ethanol Extract of Rosa canina L. fruit on Diabetic Rats: An Experimental Study With Histopathological Evaluations</atitle><jtitle>Journal of evidence-based complementary & alternative medicine</jtitle><addtitle>J Evid Based Complementary Altern Med</addtitle><date>2016-10</date><risdate>2016</risdate><volume>21</volume><issue>4</issue><spage>NP25</spage><epage>NP30</epage><pages>NP25-NP30</pages><issn>2156-5872</issn><eissn>2156-5899</eissn><abstract>Rosa canina L. 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| source | Sage Journals GOLD Open Access 2024 |
| subjects | Animals Blood Glucose - drug effects Diabetes Mellitus, Experimental - metabolism Fruit - chemistry Hypoglycemic Agents - pharmacology Hypolipidemic Agents - pharmacology Lipids - blood Male Pancreas - drug effects Pancreas - pathology Plant Extracts - pharmacology Rats Rats, Wistar Rosa - chemistry |
| title | Antidiabetic and Antihyperlipidemic Effects of Ethanol Extract of Rosa canina L. fruit on Diabetic Rats: An Experimental Study With Histopathological Evaluations |
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