Antidiabetic and Antihyperlipidemic Effects of Ethanol Extract of Rosa canina L. fruit on Diabetic Rats: An Experimental Study With Histopathological Evaluations

Rosa canina L. (Rosaceae) has been traditionally used as a medicinal plant. This study was undertaken to evaluate the antidiabetic and antihyperlipidemic effects of Rosa canina fruit extract in streptozotocin induced diabetic rats. The results showed oral administration of Rosa canina fruit extract...

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Veröffentlicht in:Journal of evidence-based complementary & alternative medicine 2016-10, Vol.21 (4), p.NP25-NP30
Hauptverfasser: Taghizadeh, Mohsen, Rashidi, Ali Akbar, Taherian, Ali Akbar, Vakili, Zarichehr, Sajad Sajadian, Mohammad, Ghardashi, Mostafa
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Sprache:eng
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Zusammenfassung:Rosa canina L. (Rosaceae) has been traditionally used as a medicinal plant. This study was undertaken to evaluate the antidiabetic and antihyperlipidemic effects of Rosa canina fruit extract in streptozotocin induced diabetic rats. The results showed oral administration of Rosa canina fruit extract significantly ameliorated the high levels of blood glucose compared with the control group. Serum triglyceride levels significantly decreased by the administration of Rosa canina extract compared with control. Histopathological examinations showed that the Rosa canina extract improved islets necrotic and regenerated pancreatic islet cells. Rosa canina extract has the antihyperglycemic and antihyperlipidemic effects in streptozotocin-induced diabetic rats.
ISSN:2156-5872
2156-5899
DOI:10.1177/2156587215612626