Oncosomes - large and small: what are they, where they came from?

In spite of its intuitive usefulness and convenient "ring," this term is often applied in ways that have little to do with its intended meaning, circumstances under which it has been coined in our respective laboratories, ontologic efficiency or any consensus in the field. [...]some context may be useful in putting things in perspective towards establishing meaningful definitions. Perhaps in this case terms such as large EVs, "megavesicles" or shed cytoplasts could be far more appropriate than "oncosomes." [...]terms "oncosomes" and "large oncosomes" are not synonymous or interchangeable. Brian Meehan Child Health and Human Development Program The Research Institute of the McGill University Health Centre Montreal, Quebec, Canada Janusz Rak Department of Pediatrics, Biochemistry and Experimental Medicine McGill University Child Health and Human Development Program The Research Institute of the McGill University Health Centre Montreal, Quebec, Canada Email: janusz.rak@mcgill.ca Dolores Di Vizio Division of Cancer Biology and Therapeutics Departments of Surgery, Biomedical Sciences and Pathology and Laboratory Medicine Samuel Oschin Comprehensive Cancer Institute Cedars-Sinai Medical Center Los Angeles, CA, United States Email: Dolores.Divizio@cshs.org References 1.