Convergent evolution of pathogenicity islands in helper cos phage interference

Staphylococcus aureus pathogenicity islands (SaPIs) are phage satellites that exploit the life cycle of their helper phages for their own benefit. Most SaPIs are packaged by their helper phages using a headful (pac) packaging mechanism. These SaPIs interfere with pac phage reproduction through a var...

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Veröffentlicht in:Philosophical transactions of the Royal Society of London. Series B. Biological sciences 2016-11, Vol.371 (1707), p.20150505-20150505
Hauptverfasser: Carpena, Nuria, Manning, Keith A., Dokland, Terje, Marina, Alberto, Penadés, José R.
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container_end_page 20150505
container_issue 1707
container_start_page 20150505
container_title Philosophical transactions of the Royal Society of London. Series B. Biological sciences
container_volume 371
creator Carpena, Nuria
Manning, Keith A.
Dokland, Terje
Marina, Alberto
Penadés, José R.
description Staphylococcus aureus pathogenicity islands (SaPIs) are phage satellites that exploit the life cycle of their helper phages for their own benefit. Most SaPIs are packaged by their helper phages using a headful (pac) packaging mechanism. These SaPIs interfere with pac phage reproduction through a variety of strategies, including the redirection of phage capsid assembly to form small capsids, a process that depends on the expression of the SaPI-encoded cpmA and cpmB genes. Another SaPI subfamily is induced and packaged by cos-type phages, and although these cos SaPIs also block the life cycle of their inducing phages, the basis for this mechanism of interference remains to be deciphered. Here we have identified and characterized one mechanism by which the SaPIs interfere with cos phage reproduction. This mechanism depends on a SaPI-encoded gene, ccm, which encodes a protein involved in the production of small isometric capsids, compared with the prolate helper phage capsids. As the Ccm and CpmAB proteins are completely unrelated in sequence, this strategy represents a fascinating example of convergent evolution. Moreover, this result also indicates that the production of SaPI-sized particles is a widespread strategy of phage interference conserved during SaPI evolution. This article is part of the themed issue ‘The new bacteriology’.
doi_str_mv 10.1098/rstb.2015.0505
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ispartof Philosophical transactions of the Royal Society of London. Series B. Biological sciences, 2016-11, Vol.371 (1707), p.20150505-20150505
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subjects Bacteriophage Packaging
Bacteriophage Resistance
Biological Evolution
Capsid Morphogenesis
Capsid Proteins - physiology
Evolution, Molecular
Genomic Islands - genetics
Picis
Sapis
Small Capsids
Staphylococcus aureus
Staphylococcus aureus - genetics
Staphylococcus aureus - virology
Staphylococcus Phages - physiology
Virus Assembly - physiology
title Convergent evolution of pathogenicity islands in helper cos phage interference
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