Design of tumor-homing and pH-responsive polypeptide-doxorubicin nanoparticles with enhanced anticancer efficacy and reduced side effects

Tumor-homing and pH-responsive polypeptide-drug nanoparticles for targeted cancer therapy are precisely designed by site-specific drug conjugation to a bioactive and well-defined elastin-like polypeptide through an acid-labile linker. In a murine cancer model, these nanoparticles show significantly...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2015-07, Vol.51 (57), p.11405-11408
Hauptverfasser:	Hu, Jin, Xie, Lining, Zhao, Wenguo, Sun, Mengmeng, Liu, Xinyu, Gao, Weiping
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibiotics, Antineoplastic - administration & dosage Antibiotics, Antineoplastic - adverse effects Antibiotics, Antineoplastic - pharmacokinetics Antibiotics, Antineoplastic - therapeutic use Biocompatibility Cancer Cell Line, Tumor Conjugation Delayed-Action Preparations - adverse effects Delayed-Action Preparations - chemistry Doxorubicin - administration & dosage Doxorubicin - adverse effects Doxorubicin - pharmacokinetics Doxorubicin - therapeutic use Drug Delivery Systems Drugs Effectiveness Elastin - adverse effects Elastin - chemistry Humans Hydrogen-Ion Concentration Mice Molecular Sequence Data Nanoparticles Nanoparticles - adverse effects Nanoparticles - chemistry Neoplasms - drug therapy Neoplasms - pathology Peptides - adverse effects Peptides - chemistry Side effects Toxicity
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