Design of tumor-homing and pH-responsive polypeptide-doxorubicin nanoparticles with enhanced anticancer efficacy and reduced side effects

Tumor-homing and pH-responsive polypeptide-drug nanoparticles for targeted cancer therapy are precisely designed by site-specific drug conjugation to a bioactive and well-defined elastin-like polypeptide through an acid-labile linker. In a murine cancer model, these nanoparticles show significantly...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2015-07, Vol.51 (57), p.11405-11408
Hauptverfasser:	Hu, Jin, Xie, Lining, Zhao, Wenguo, Sun, Mengmeng, Liu, Xinyu, Gao, Weiping
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibiotics, Antineoplastic - administration & dosage Antibiotics, Antineoplastic - adverse effects Antibiotics, Antineoplastic - pharmacokinetics Antibiotics, Antineoplastic - therapeutic use Biocompatibility Cancer Cell Line, Tumor Conjugation Delayed-Action Preparations - adverse effects Delayed-Action Preparations - chemistry Doxorubicin - administration & dosage Doxorubicin - adverse effects Doxorubicin - pharmacokinetics Doxorubicin - therapeutic use Drug Delivery Systems Drugs Effectiveness Elastin - adverse effects Elastin - chemistry Humans Hydrogen-Ion Concentration Mice Molecular Sequence Data Nanoparticles Nanoparticles - adverse effects Nanoparticles - chemistry Neoplasms - drug therapy Neoplasms - pathology Peptides - adverse effects Peptides - chemistry Side effects Toxicity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Tumor-homing and pH-responsive polypeptide-drug nanoparticles for targeted cancer therapy are precisely designed by site-specific drug conjugation to a bioactive and well-defined elastin-like polypeptide through an acid-labile linker. In a murine cancer model, these nanoparticles show significantly better anti-tumor efficacy and less systemic toxicity than not only free drugs, but also polypeptide-drug nanoparticles without the tumor-homing function.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c5cc04035c