Four residues of propeptide are essential for precursor folding of nattokinase

Subtilisin propeptide functions as an intramolecular chaperone that guides precursor folding. Nattokinase, a member of subtilisin family, is synthesized as a precursor consisting of a signal peptide, a propeptide, and a subtilisin domain, and the mechanism of its folding remains to be understood. In...

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Veröffentlicht in:	Acta biochimica et biophysica Sinica 2014-11, Vol.46 (11), p.957-964
Hauptverfasser:	Jia, Yan, Cao, Xinhua, Deng, Yu, Bao, Wei, Tang, Changyan, Ding, Hanjing, Zheng, Zhongliang, Zou, Guolin
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Bacillus subtilis - enzymology Bacillus subtilis - genetics Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Conserved Sequence Enzyme Precursors - chemistry Enzyme Precursors - genetics Enzyme Precursors - metabolism Kinetics Models, Molecular Molecular Sequence Data Mutagenesis, Site-Directed Protein Folding Protein Interaction Domains and Motifs Protein Structure, Secondary Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Sequence Homology, Amino Acid Subtilisins - chemistry Subtilisins - genetics Subtilisins - metabolism 前体前肽动力学参数多点突变折叠枯草杆菌蛋白酶残基纳豆激酶
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