Bone marrow B lymphocytes in multiple myeloma and MGUS: focus on distribution of naïve cells and memory subsets

Highlights • Bone marrow B cell subsets are differentially distributed in myeloma patients. • Fraction of DN B cells is increased in patients unable to reach complete response. • Naïve/transitional B cells are expanded in stringent complete responders. • DN and naïve/transitional B cells may be moni...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Leukemia research 2016-10, Vol.49, p.51-59
Hauptverfasser:	Pojero, Fanny, Casuccio, Alessandra, Giambanco, Caterina, Bulati, Matteo, Buffa, Silvio, Bassiano, Francesco Di, Gervasi, Francesco, Caruso, Calogero, Romano, Giuseppina Colonna
Format:	Artikel
Sprache:	eng
Schlagworte:	B cells B-Lymphocyte Subsets B-Lymphocytes - immunology Bone Marrow Cells - immunology Case-Control Studies Female Flow Cytometry Hematology, Oncology and Palliative Medicine Humans Immunoglobulin D - analysis Male MGUS Monoclonal Gammopathy of Undetermined Significance - immunology Monoclonal Gammopathy of Undetermined Significance - pathology Multiple myeloma Multiple Myeloma - immunology Multiple Myeloma - pathology Tumor Necrosis Factor Receptor Superfamily, Member 7 - analysis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • Bone marrow B cell subsets are differentially distributed in myeloma patients. • Fraction of DN B cells is increased in patients unable to reach complete response. • Naïve/transitional B cells are expanded in stringent complete responders. • DN and naïve/transitional B cells may be monitored with predictive purposes
ISSN:	0145-2126 1873-5835
DOI:	10.1016/j.leukres.2016.08.008